A Feasibility Study Evaluating the Performance of Focused Multipolar Stimulation in Adult Cochlear Implant Recipients

NCT ID: NCT05003674

Last Updated: 2025-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-28

Study Completion Date

2025-04-07

Brief Summary

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This feasibility study is designed to explore several facets of hearing performance that may show improvements for alternative modes of stimulation compared to Monopolar (MP) stimulation within a group of adult cochlear-implant recipients. Measures of speech recognition, music appreciation, listening effort, quality of life, and real-world assessments will be gathered to determine the most promising benefits for further examination.

Detailed Description

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Alternative modes of stimulation will be investigated that may improve spectral resolution through reduced cochlear spread of excitation and in turn provide enhanced speech perception and real-world clinical benefits over MP stimulation. The purpose of this feasibility study is to explore several facets of hearing performance that may show improvements with these alternative modes of stimulation compared to MP stimulation within a group of adult cochlear-implant recipients. Measures of speech recognition, music appreciation, listening effort, quality of life, and real-world assessments will be gathered to determine the most promising benefits for further examination. Individual neural, psychophysical, cognitive, and electrode placement data will also be obtained to inform questions related to across-subject variability, and practical aspects of power consumption and device fitting will be evaluated.

Conditions

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Hearing Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Adults cochlear implant recipients receiving alternative stimulation strategy

ACE strategy, 8 maxima, alternative mode

Group Type EXPERIMENTAL

Focused stimulation strategy

Intervention Type DEVICE

Investigational focused stimulation strategy

Adults cochlear implant recipients receiving Standard-of-Care stimulation strategy.

ACE strategy, 8 maxima, monopolar mode.

Group Type ACTIVE_COMPARATOR

ACE stimulation strategy

Intervention Type DEVICE

Standard of care stimulation strategy

Interventions

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Focused stimulation strategy

Investigational focused stimulation strategy

Intervention Type DEVICE

ACE stimulation strategy

Standard of care stimulation strategy

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Adults 18 years of age or older.
2. Candidate for unilateral cochlear implant with Slim Modiolar electrode array as determined by the implanting centre.
3. English spoken as a primary language.
4. Willingness to comply with all investigational requirements.
5. Willing and able to provide written informed consent.

Exclusion Criteria

1. Previous or existing cochlear-implant recipient.
2. Evidence of severe or greater sensorineural hearing loss prior to five years of age.
3. Open-set pre-operative word score \> 70% in the contralateral ear.
4. Duration of severe to profound hearing loss \> 20 years in the ear to be implanted.
5. Adults with functional acoustic hearing in the ear to be implanted who desire to use an acoustic component in the implanted ear.
6. Ossification or other cochlear anomaly that might prevent complete insertion of the electrode array.
7. Hearing loss of neural or central origin.
8. Medical or psychological conditions that would contraindicate undergoing surgery.
9. Women who are pregnant.
10. Additional handicaps that would prevent or restrict participation in the audiological evaluations.
11. Unrealistic expectations on the part of the subject regarding the possible benefits, risks, and limitations that are inherent to the surgical procedure and prosthetic device.
12. Inability or unwillingness to use a hand-held device to control the sound processor and to collect test and survey data.
13. Unable or unwilling to comply with the requirements of the clinical investigation as determined by the Investigator.
14. Investigator site personnel directly affiliated with this study and/or their immediate families; immediate family is defined as a spouse, parent, child, or sibling.
15. Cochlear employees or employees of Contract Research Organisations or contractors engaged by Cochlear for the purposes of this investigation.
16. Currently participating, or participated within the last 30 days, in another interventional clinical investigation/trial involving an investigational drug or device.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cochlear

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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NextSense - Deakin

Deakin, Australian Capital Territory, Australia

Site Status

NextSense - Broadmeadow

Broadmeadow, New South Wales, Australia

Site Status

Royal Victorian Eye and Ear Hospital

East Melbourne, Victoria, Australia

Site Status

St Vincent's Private Hospital

East Melbourne, Victoria, Australia

Site Status

Countries

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Australia

Other Identifiers

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AI5782

Identifier Type: -

Identifier Source: org_study_id

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