Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
240 participants
INTERVENTIONAL
2022-02-28
2026-01-28
Brief Summary
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Data are however scarce and physiopathological mechanisms have not been assessed to date.
The investigators hypothesize a global lymphocyte innateness in SSc, linked to a chronic ITC stimulation by innate signals leading to ITC exhaustion, and their potential role in endotheliopathy and fibroblast activation in SSc.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Blood test
Unique blood test for all the participants included in the study to constitute a local biobank to assess in a grouped manner the prespecified outcomes
Blood test
Unique blood draw of 45mL for all the participants
Interventions
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Blood test
Unique blood draw of 45mL for all the participants
Eligibility Criteria
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Inclusion Criteria
* Patients with others connective tissue disease:
* Systemic erythematosus lupus (SLE) according to the 2019 ACR/EULAR criteria
* Primary Sjögren syndrome (pSS) according to the 2016 ACR/EULAR criteria
* Rheumatoid arthritis according to the 2010 ACR/EULAR criteria
* Idiopathic inflammatory myopathy (IIM) according to the 2017 ACR/EULAR criteria
* Healthy subjects from general population without known autoimmune disease or connective tissue disease
* ≥18 years-old
Exclusion Criteria
* Weight \<55 kgs
* Known primary cell immunodeficiency
* Past of autologous or allogenic hematopoietic stem cell transplantation
* Solid neoplasia or malignant hemopathy in remission for less than 12 months an
* Chemotherapy and/or immune checkpoint inhibitors in the last 12 months
* Systemic retinoids
* Active infection and/or antibiotics in the last 2 weeks
* Known active chronic infection among HIV, HTLV, viral hepatitis, syphilis
* Vaccination in the last 4 weeks
* Subject refusing genetic analysis for the present study
* Pregnancy or breastfeeding
18 Years
ALL
Yes
Sponsors
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Poitiers University Hospital
OTHER
Responsible Party
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Locations
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CHU poitiers
Poitiers, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Sclero-LTI
Identifier Type: -
Identifier Source: org_study_id
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