Real-world Evidence of COVID-19 Vaccines Effectiveness

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

182 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-16

Study Completion Date

2022-07-19

Brief Summary

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This is an observational case-control study to evaluate COVID-19 vaccine effectiveness against hospitalisation with COVID-19 related conditions in St. Petersburg, Russia. Two sets of cases and control will be retrospectively analyzed to compare vaccination proportions and other characteristics to infer vaccine effectiveness from odds ratios. The first set of cases will be extracted from the data on hospitalisation of patients with COVID-19 to First Pavlov State Medical University of Saint-Petersburg hospitals, and controls will be patients hospitalised with other conditions. The second set of cases and controls will be based on patients referred to Medical Institute named after Berezin Sergey for computed tomography. Cases will be patients with positive SARS-CoV-2 status computed tomography confirmed pneumonia or patients referred to hospitalisation, and control will be patients without pneumonia and not referred to hospitalisation.

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Detailed Description

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Conditions

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COVID-19 Pneumonia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients hospitalised to clinics of First Pavlov State Medical University of Saint - Petersburg

450 cases - patients hospitalised with COVID-19 450 control - patients hospitalised without COVID-19 in the same period (surgical, oncological, cardiological, ophthalmologic, gastroenterological departments)

COVID-19 Vaccines

Intervention Type BIOLOGICAL

"Gam-COVID-Vac" "EpiVacCorona" "COVIVAC"

Patients referred to Medical Institute named after Berezin Sergey for computed tomography

Cases - patients with pneumonia confirmed after computed tomography. Controls - patients without pneumonia after computed tomography.

COVID-19 Vaccines

Intervention Type BIOLOGICAL

"Gam-COVID-Vac" "EpiVacCorona" "COVIVAC"

Interventions

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COVID-19 Vaccines

"Gam-COVID-Vac" "EpiVacCorona" "COVIVAC"

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients hospitalized to clinics of First Pavlov State Medical University of Saint-Petersburg
* Patients referred to Medical Institute named after Berezin Sergey for computed tomography
* Available vaccination status