Recovery After Intensive Care Study

NCT ID: NCT04979741

Last Updated: 2021-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

196 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2023-01-01

Brief Summary

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Post-ICU long term sequelae- defined as "post intensive care syndrome" (PICS) manifest with a wide spectrum of psychological and cognitive impairments, affecting over two-thirds of ICU survivors and leading to increased rehospitalization, health care costs, impaired quality of life (QoL), inability to return to work and burden for families.

The prevalence of post-traumatic stress symptoms (PTSD), anxiety symptoms, and depression after ICU stay is high and has been demonstrated in up to 50% of post-ICU population.

Therefore, over the last years, an important effort has been made for the development of ICU aftercare and follow-up clinics with the aim to detect and to minimize post-ICU sequelae and improve outcomes. However, the utility of these follow-up programs and their effect on outcome has not been completely demonstrated.

Detailed Description

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This is a single center, prospective observational study, which will be conducted at Policlinico San Martino Hospital, Genova, Italy. Patients admitted to the ICU from more than 72 hours will be consecutively included during a 2 years period.

The primary objective is to assess the incidence of post-discharge mortality in patients admitted in ICU at 12 months.

Secondary objectives include the evaluation at 3, 6 and 12 months of outcome of patients admitted in ICU assessing QoL, anxiety, depression, PTSD, physical ability, cognitive function, sleep disorder and return to previous life; Self- and observer reported cognitive disability at 6 and 12 months after ICU discharge; prognostic factors for poor outcome, and emotional and burden of care impact on the patient's caregivers.

Conditions

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Follow up Outcome Intensive Care Unit Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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No interventions

Observational study, no intervention is required

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years;
* All patients acutely admitted in the ICU from \>72 hours, for both medical and surgical pathologies.

Exclusion Criteria

* Pregnancy;
* Refuse of consent to enrolment of patient or of the doctor required to give his approval.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Genova

OTHER

Sponsor Role lead

Responsible Party

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Paolo Pelosi

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Policlinico San Martino

Genova, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Iole Brunetti, MD

Role: CONTACT

Facility Contacts

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Iole Brunetti, MD

Role: primary

010/55510

Other Identifiers

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Protocol approval

Identifier Type: OTHER

Identifier Source: secondary_id

CER Liguria: 350/2019

Identifier Type: -

Identifier Source: org_study_id

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