SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial

NCT ID: NCT04972721

Last Updated: 2025-10-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-01

Study Completion Date

2033-11-30

Brief Summary

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Participants are being asked to participate in SELECT-LIFE study because participants take part in the SELECT trial.

SELECT-LIFE study is a survey-based study that will start when the SELECT trial ends.

SELECT-LIFE looks at the long-term effects of participants taking part in the SELECT trial including the trial medicine participants have been taking.

When the SELECT trial ends, participants will no longer get the medicine participants got in the study, even if participants decide to take part in the SELECT-LIFE study.

Participants will not get any specific treatment or medicine as part of the SELECT-LIFE study, and participants will be treated as participants normally would by their own doctor.

The SELECT-LIFE study will last for up to 10 years after SELECT trial ends, and participants will be asked to fill in a questionnaire about their health every 6 months.

Detailed Description

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Conditions

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Overweight Obesity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Questionnaire survey

Participants of the SELECT trial (EX9536-4388 ) are invited to transition to SELECT-LIFE (follow-up study) when SELECT ends.

No treatment given

Intervention Type OTHER

The study is non-interventional with no study-specific treatment during the study and the patients will be treated as per Treating Physician's and patient's own discretion.

Interventions

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No treatment given

The study is non-interventional with no study-specific treatment during the study and the patients will be treated as per Treating Physician's and patient's own discretion.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Randomized into the SELECT clinical trial (EX9536-4388) and has not withdrawn consent, regardless of level of participation, dose achieved or treatment discontinuation.
* Signed SELECT-LIFE consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol).

Exclusion Criteria

* Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Transparency (dept. 2834)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Master Centre for USA

Plainsboro, New Jersey, United States

Site Status RECRUITING

Master Centre for Algeria

Algiers, , Algeria

Site Status RECRUITING

Master Centre for Argentina

Prov. de Buenos Aires, , Argentina

Site Status RECRUITING

Master Centre for Australia

North Sydney, New South Wales, Australia

Site Status RECRUITING

Cárdio Pulmonar da Bahia

Salvador, Estado de Bahia, Brazil

Site Status ENROLLING_BY_INVITATION

Hospital do Coração do Brasil

Brasília, Federal District, Brazil

Site Status ENROLLING_BY_INVITATION

Eurolatino Medical Research Center

Uberlândia, Minas Gerais, Brazil

Site Status ENROLLING_BY_INVITATION

Núcleo de Pesquisa Clínica S/S

Curitiba, Paraná, Brazil

Site Status ENROLLING_BY_INVITATION

Hospital São Vicente de Paulo

Passo Fundo, Rio Grande do Sul, Brazil

Site Status ENROLLING_BY_INVITATION

AngioCor Blumenau

Blumenau, Santa Catarina, Brazil

Site Status ENROLLING_BY_INVITATION

Instituto de Pesquisa Clínica de Campinas

Campinas, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

CIP Centro Integrado de Pesquisas do Hospital de Base

São José do Rio Preto, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

CPQuali Pesquisa Clínica Ltda

São Paulo, São Paulo, Brazil

Site Status RECRUITING

CPCLIN - Centro de Pesquisas Clínicas

São Paulo, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

Instituto Dante Pazzanese de Cardiologia

São Paulo, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

Departamento de Gastroenterologia - HCFMUSP

São Paulo, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

Instituto do Coração - HCFMUSP

São Paulo, São Paulo, Brazil

Site Status ENROLLING_BY_INVITATION

Master Centre for Brazil

Säo Paulo, São Paulo, Brazil

Site Status RECRUITING

Instituto Brasil de Pesquisa Clinica

Rio de Janeiro, , Brazil

Site Status ENROLLING_BY_INVITATION

Master Centre for Canada

Mississauga, Ontario, Canada

Site Status RECRUITING

Novo Nordisk Croatia Ltd.

Zagreb, , Croatia

Site Status RECRUITING

Master Centre for Denmark

Copenhagen S, , Denmark

Site Status RECRUITING

Master Centre for Finland

Espoo, , Finland

Site Status RECRUITING

Master Centre for Germany PMS

Mainz, , Germany

Site Status ACTIVE_NOT_RECRUITING

Master Centre for Greece

Vouliagment, , Greece

Site Status RECRUITING

Master centre for India

Bangalore, , India

Site Status ENROLLING_BY_INVITATION

Master Centre for Ireland

Dublin, , Ireland

Site Status ENROLLING_BY_INVITATION

Master Centre for Italy

Rome, , Italy

Site Status RECRUITING

Master Centre for Japan

Tokyo, , Japan

Site Status ENROLLING_BY_INVITATION

MAster Centre for Latvia

Marupes, , Latvia

Site Status ENROLLING_BY_INVITATION

Master Centre for Malaysia

Selangor Darul Ehsan, , Malaysia

Site Status RECRUITING

Master Centre Netherlands

Alphen aan den Rijn, , Netherlands

Site Status ENROLLING_BY_INVITATION

Master Centre for Norway

Rud, , Norway

Site Status ENROLLING_BY_INVITATION

Master Centre for South Africa

Sandton, Gauteng, South Africa

Site Status RECRUITING

Master Centre for Sweden

Malmo, , Sweden

Site Status ENROLLING_BY_INVITATION

Master Centre for Tawain

Taipei, , Taiwan

Site Status RECRUITING

Master Centre for Thailand

Bangkok, , Thailand

Site Status RECRUITING

Master Centre for United Kingdom

Gatwick, West Sussex, United Kingdom

Site Status RECRUITING

Countries

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United States Algeria Argentina Australia Brazil Canada Croatia Denmark Finland Germany Greece India Ireland Italy Japan Latvia Malaysia Netherlands Norway South Africa Sweden Taiwan Thailand United Kingdom

Central Contacts

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Novo Nordisk

Role: CONTACT

(+1) 866-867-7178

Other Identifiers

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U1111-1255-5644

Identifier Type: OTHER

Identifier Source: secondary_id

EX9536-4750

Identifier Type: -

Identifier Source: org_study_id

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