Resuscitative TEE Collaborative Registry

NCT ID: NCT04972526

Last Updated: 2026-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2027-12-15

Brief Summary

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The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused TEE.

The primary objective of this study is to determine the clinical impact and safety of TEE performed during the evaluation of critically-ill patients in the emergency department and intensive care settings.

The secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.

Detailed Description

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Vision

The Resuscitative TEE Collaborative Registry aims to accelerate the development of outcome-oriented research and knowledge translation on the use of TEE in emergency and critical care settings.

Mission

The registry aims to catalyze clinical research involving the use of TEE in critically-ill patients through the following strategic initiatives:

* Facilitate collaboration between different clinical teams and organizations across the entire spectrum of users of TEE in acute care setting, including emergency departments and intensive care units.
* Standardize data collection and reporting that enables multi-institutional data sharing.
* Provide an efficient research infrastructure that facilitates data capture, management and analysis, enabling teams around the world to conduct research studies in this field.
* Make shared data open and accessible to clinicians and researchers.

Conditions

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Cardiac Arrest Cardiac Arrest Circulatory Cardiac Arrest, Out-Of-Hospital Shock Hemodynamic Instability

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Out-of-hospital Cardiac Arrest

Patients receiving TEE as part of their clinical evaluation during cardiac arrest that occurred outside the hospital (e.g. in/at a home or residence, in a public area, during transport to the emergency department, etc.)

No interventions assigned to this group

In-hospital Cardiac Arrest

Patients receiving TEE as part of the clinical evaluation during cardiac arrest that occurred within a hospital (e.g in the emergency department, an Intensive Care Unit, a hospital ward, the operating room, etc.)

No interventions assigned to this group

Undifferentiated Shock or Acute Hemodynamic Decompensation

Patients receiving TEE as part of the initial evaluation of undifferentiated shock or acute hemodynamic decompensation

No interventions assigned to this group

Hemodynamic Monitoring in a Critically Ill Patient

Critically ill patients receiving TEE as part of hemodynamic monitoring

No interventions assigned to this group

Procedural Guidance

Patients receiving TEE as a means to assist providers performing procedures (e.g. intravenous pacemaker placement, veno-arterial or veno-venous extracorporeal membrane oxygenation \[ECMO\], impella heart pump placement, intra-aortic balloon pump placement, etc.)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adult critically-ill patients who as part of their routine clinical care receive focused TEE in the emergency department of intensive care setting.

Exclusion Criteria

* Children (age under 18 years)
* Vulnerable populations
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Weill Medical College of Cornell University

OTHER

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role lead

Responsible Party

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Felipe Teran, MD, MSCE

Chair, Resuscitative TEE Collaborative Registry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Felipe Teran, MD, MSCE

Role: PRINCIPAL_INVESTIGATOR

Weill Medical College of Cornell University

Clark G Owyang, MD

Role: STUDY_CHAIR

Weill Medical College of Cornell University

Locations

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University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Caleb Suh

Role: CONTACT

5715674373

Felipe Teran, MD, MSCE

Role: CONTACT

9172573841

Facility Contacts

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Eileen McDonnell

Role: primary

215-746-5610

References

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Teran F, Prats MI, Nelson BP, Kessler R, Blaivas M, Peberdy MA, Shillcutt SK, Arntfield RT, Bahner D. Focused Transesophageal Echocardiography During Cardiac Arrest Resuscitation: JACC Review Topic of the Week. J Am Coll Cardiol. 2020 Aug 11;76(6):745-754. doi: 10.1016/j.jacc.2020.05.074.

Reference Type BACKGROUND
PMID: 32762909 (View on PubMed)

Teran F, Burns KM, Narasimhan M, Goffi A, Mohabir P, Horowitz JM, Yuriditsky E, Nagdev A, Panebianco N, Chin EJ, Gottlieb M, Koenig S, Arntfield R. Critical Care Transesophageal Echocardiography in Patients during the COVID-19 Pandemic. J Am Soc Echocardiogr. 2020 Aug;33(8):1040-1047. doi: 10.1016/j.echo.2020.05.022. Epub 2020 May 23.

Reference Type BACKGROUND
PMID: 32600742 (View on PubMed)

Teran F, Dean AJ, Centeno C, Panebianco NL, Zeidan AJ, Chan W, Abella BS. Evaluation of out-of-hospital cardiac arrest using transesophageal echocardiography in the emergency department. Resuscitation. 2019 Apr;137:140-147. doi: 10.1016/j.resuscitation.2019.02.013. Epub 2019 Feb 16.

Reference Type BACKGROUND
PMID: 30779977 (View on PubMed)

Arntfield R, Lau V, Landry Y, Priestap F, Ball I. Impact of Critical Care Transesophageal Echocardiography in Medical-Surgical ICU Patients: Characteristics and Results From 274 Consecutive Examinations. J Intensive Care Med. 2020 Sep;35(9):896-902. doi: 10.1177/0885066618797271. Epub 2018 Sep 6.

Reference Type BACKGROUND
PMID: 30189783 (View on PubMed)

Lerner RP, Haaland A, Lin J. Temporary transvenous pacer placement under transesophageal echocardiogram guidance in the Emergency Department. Am J Emerg Med. 2020 May;38(5):1044.e3-1044.e4. doi: 10.1016/j.ajem.2019.12.027. Epub 2019 Dec 16.

Reference Type BACKGROUND
PMID: 31870671 (View on PubMed)

Catena E, Ottolina D, Fossali T, Rech R, Borghi B, Perotti A, Ballone E, Bergomi P, Corona A, Castelli A, Colombo R. Association between left ventricular outflow tract opening and successful resuscitation after cardiac arrest. Resuscitation. 2019 May;138:8-14. doi: 10.1016/j.resuscitation.2019.02.027. Epub 2019 Feb 27.

Reference Type BACKGROUND
PMID: 30825552 (View on PubMed)

Osman A, Fong CP, Wahab SFA, Panebianco N, Teran F. Transesophageal Echocardiography at the Golden Hour: Identification of Blunt Traumatic Aortic Injuries in the Emergency Department. J Emerg Med. 2020 Sep;59(3):418-423. doi: 10.1016/j.jemermed.2020.05.003. Epub 2020 Jun 23.

Reference Type BACKGROUND
PMID: 32591302 (View on PubMed)

Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.

Reference Type BACKGROUND
PMID: 19732038 (View on PubMed)

Fair J 3rd, Mallin MP, Adler A, Ockerse P, Steenblik J, Tonna J, Youngquist ST. Transesophageal Echocardiography During Cardiopulmonary Resuscitation Is Associated With Shorter Compression Pauses Compared With Transthoracic Echocardiography. Ann Emerg Med. 2019 Jun;73(6):610-616. doi: 10.1016/j.annemergmed.2019.01.018. Epub 2019 Feb 14.

Reference Type BACKGROUND
PMID: 30773413 (View on PubMed)

Parker BK, Salerno A, Euerle BD. The Use of Transesophageal Echocardiography During Cardiac Arrest Resuscitation: A Literature Review. J Ultrasound Med. 2019 May;38(5):1141-1151. doi: 10.1002/jum.14794. Epub 2018 Oct 2.

Reference Type BACKGROUND
PMID: 30280396 (View on PubMed)

Teran F. Resuscitative Cardiopulmonary Ultrasound and Transesophageal Echocardiography in the Emergency Department. Emerg Med Clin North Am. 2019 Aug;37(3):409-430. doi: 10.1016/j.emc.2019.03.003. Epub 2019 May 21.

Reference Type BACKGROUND
PMID: 31262412 (View on PubMed)

Jaidka A, Hobbs H, Koenig S, Millington SJ, Arntfield RT. Better With Ultrasound: Transesophageal Echocardiography. Chest. 2019 Jan;155(1):194-201. doi: 10.1016/j.chest.2018.09.023. Epub 2018 Oct 9.

Reference Type BACKGROUND
PMID: 30312590 (View on PubMed)

Vieillard-Baron A, Chergui K, Rabiller A, Peyrouset O, Page B, Beauchet A, Jardin F. Superior vena caval collapsibility as a gauge of volume status in ventilated septic patients. Intensive Care Med. 2004 Sep;30(9):1734-9. doi: 10.1007/s00134-004-2361-y. Epub 2004 Jun 26.

Reference Type BACKGROUND
PMID: 15375649 (View on PubMed)

Blaivas M. Transesophageal echocardiography during cardiopulmonary arrest in the emergency department. Resuscitation. 2008 Aug;78(2):135-40. doi: 10.1016/j.resuscitation.2008.02.021. Epub 2008 May 16.

Reference Type BACKGROUND
PMID: 18486300 (View on PubMed)

Arntfield R, Pace J, McLeod S, Granton J, Hegazy A, Lingard L. Focused transesophageal echocardiography for emergency physicians-description and results from simulation training of a structured four-view examination. Crit Ultrasound J. 2015 Dec;7(1):27. doi: 10.1186/s13089-015-0027-3. Epub 2015 Jun 12.

Reference Type BACKGROUND
PMID: 26123608 (View on PubMed)

Arntfield R, Pace J, Hewak M, Thompson D. Focused Transesophageal Echocardiography by Emergency Physicians is Feasible and Clinically Influential: Observational Results from a Novel Ultrasound Program. J Emerg Med. 2016 Feb;50(2):286-94. doi: 10.1016/j.jemermed.2015.09.018. Epub 2015 Oct 24.

Reference Type BACKGROUND
PMID: 26508495 (View on PubMed)

Fair J, Tonna J, Ockerse P, Galovic B, Youngquist S, McKellar SH, Mallin M. Emergency physician-performed transesophageal echocardiography for extracorporeal life support vascular cannula placement. Am J Emerg Med. 2016 Aug;34(8):1637-9. doi: 10.1016/j.ajem.2016.06.038. Epub 2016 Jun 7.

Reference Type BACKGROUND
PMID: 27318746 (View on PubMed)

Byars DV, Tozer J, Joyce JM, Vitto MJ, Taylor L, Kayagil T, Jones M, Bishop M, Knapp B, Evans D. Emergency Physician-performed Transesophageal Echocardiography in Simulated Cardiac Arrest. West J Emerg Med. 2017 Aug;18(5):830-834. doi: 10.5811/westjem.2017.5.33543. Epub 2017 Jul 19.

Reference Type BACKGROUND
PMID: 28874934 (View on PubMed)

Fair J, Mallin M, Mallemat H, Zimmerman J, Arntfield R, Kessler R, Bailitz J, Blaivas M. Transesophageal Echocardiography: Guidelines for Point-of-Care Applications in Cardiac Arrest Resuscitation. Ann Emerg Med. 2018 Feb;71(2):201-207. doi: 10.1016/j.annemergmed.2017.09.003. Epub 2017 Nov 6.

Reference Type BACKGROUND
PMID: 29107407 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Related Links

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https://www.med.upenn.edu/resuscitation/rteecore/

Registry Home at the Center for Resuscitation Science

https://www.resuscitativetee.com

Resuscitative TEE Project Home

Other Identifiers

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844522

Identifier Type: -

Identifier Source: org_study_id

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