Effect of Es-ketamine on Postoperative Delirium Among Old Patients With Lobectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-31

Study Completion Date

2022-12-31

Brief Summary

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The purpose of this study is the efficiency of es-ketamine on postoperative delirium among old patients with elective lobectomy

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Detailed Description

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This study aimed to investigate the effect of IV es-ketamine vs saline on the incidence of postoperative delirium. It was hypothesized that IV es-ketamine would reduce the incidence of in-hospital delirium during cardiac surgery lobectomy

Conditions

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Postoperative Delirium

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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es-ketamine

es-ketamine 0.5mg/kg iv

Group Type EXPERIMENTAL

lobectomy

Intervention Type PROCEDURE

Intravenous es-ketamine 0.5mg/kg or saline during lobectomy

saline

iv saline with the same volume of es-ketamine

Group Type PLACEBO_COMPARATOR

lobectomy

Intervention Type PROCEDURE

Intravenous es-ketamine 0.5mg/kg or saline during lobectomy

Interventions

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lobectomy

Intravenous es-ketamine 0.5mg/kg or saline during lobectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 60 years old; There is no limit on the gender, ASA (American Society of Anesthesiologists )Ⅰ-Ⅲ

Exclusion Criteria

* Emergency surgery, severe hepatic and renal dysfunction, shock or coma, psychiatric disease or central nervous system disorder or a history of long-term use of psychiatric medications, cognitive dysfunction, severe arrhythmia or bradycardia, ketamine allergy,drug abuse history and used other sedatives for nearly a week

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No