A Clinical Translational Study on Repairing Articular Cartilage Injury With Autologous Adipose Gel
NCT ID: NCT04955548
Last Updated: 2021-07-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
66 participants
INTERVENTIONAL
2021-12-01
2023-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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arthroscopic microfracture with autologous adipose gel
The experimental group will be treated with arthroscopic microfracture with autologous adipose gel.
arthroscopic micro-fracture with autologous adipose gel
Fully cut the adipose tissue taken out under the arthroscopy, transfer the cut adipose tissue to a syringe connected with a double pass, push back and forth through the syringe to physically emulsify the adipose, and centrifuge to obtain the autologous adipose gel, and inject it into the lesion
arthroscopic microfracture
The control group will be treated with arthroscopic microfracture.
arthroscopic micro-fracture
Surgeons routinely perform international standard micro-fracture surgery to repair cartilage damage
Interventions
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arthroscopic micro-fracture with autologous adipose gel
Fully cut the adipose tissue taken out under the arthroscopy, transfer the cut adipose tissue to a syringe connected with a double pass, push back and forth through the syringe to physically emulsify the adipose, and centrifuge to obtain the autologous adipose gel, and inject it into the lesion
arthroscopic micro-fracture
Surgeons routinely perform international standard micro-fracture surgery to repair cartilage damage
Eligibility Criteria
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Inclusion Criteria
2. Patients with knee articular cartilage defect area ≥2cm2 and ≤8cm2, who can undergo microfracture surgery, no surgical contraindications
3. Patients voluntarily participate in clinical trials, sign an informed consent form, and be able to cooperate with clinical follow-up
Exclusion Criteria
2. Unable to accept autologous fat glue due to religion, ethnicity, etc.
3. Injury area \<2 cm2 or \>8cm2 or lack of normal cartilage tissue surrounding the injury
4. Those with compound multiple ligament injuries
5. Those with systemic immune diseases or systemic or local infections
6. Those with joint fibrosis, joint ankylosis, and obvious limitation of movement
7. People with moderate to severe osteoarthritis
8. Those who have contraindications to MRI examination
9. Patients with hemophilia
10. People whose general condition cannot tolerate surgery
11. Women who are pregnant or planning to become pregnant and women who are breastfeeding
12. Mental abnormalities and no behavioral autonomy
13. Other circumstances in which the doctor judges that he cannot participate in the trial
18 Years
60 Years
ALL
No
Sponsors
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Peking University Third Hospital
OTHER
Responsible Party
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Principal Investigators
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Yingfang Ao, Prof.
Role: PRINCIPAL_INVESTIGATOR
Peking University Third Hospital
Locations
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Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries， Beijing, China
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Other Identifiers
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M2020311
Identifier Type: -
Identifier Source: org_study_id
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