Efficacy of NIV Masks in COPD

NCT ID: NCT04947852

Last Updated: 2022-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-28

Study Completion Date

2022-03-17

Brief Summary

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A randomized controlled pilot study to compare the efficacy and tolerability of a two different NIV masks on carbon dioxide in participants with stable chronic obstructive pulmonary disease (COPD) with chronic type II respiratory failure.

Detailed Description

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Conditions

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COPD

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Investigation Mask

Bi Level CPAP Mask

Group Type EXPERIMENTAL

Investigation Mask

Intervention Type DEVICE

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Comparator Mask

Intervention Type DEVICE

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Comparator Mask

Bi Level CPAP Mask

Group Type ACTIVE_COMPARATOR

Investigation Mask

Intervention Type DEVICE

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Comparator Mask

Intervention Type DEVICE

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Interventions

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Investigation Mask

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Intervention Type DEVICE

Comparator Mask

Oronasal bilevel continuous positive airway pressure mask fitted by the investigational staff

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* A doctor's diagnosis of COPD
* PtCO2 ≥45mmHg on transcutaneous monitor at baseline measure
* Oxygen saturation measured by pulse oximetry (SpO2) ≥85%
* Fits the study mask
* Can tolerate the therapy

Exclusion Criteria

* FEV1/FVC ≥70%
* Body mass index \>35
* Hypercapnia considered to be primarily due to Obesity Hypoventilation syndrome and/or Obstructive Sleep Apnea
* Any condition which makes NIV contra-indicated as per BTS guidelines based on clinical judgement
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fisher and Paykel Healthcare

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alex Semprini

Role: PRINCIPAL_INVESTIGATOR

Medical Research Institute of New Zealand

Locations

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Medical Research Institute New Zealand

Wellington, , New Zealand

Site Status

Countries

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New Zealand

Other Identifiers

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CIA293

Identifier Type: -

Identifier Source: org_study_id

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