Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA)

NCT ID: NCT04946500

Last Updated: 2021-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-15

Study Completion Date

2021-10-15

Brief Summary

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The alternatives to the combination of Fluoroquinolone and Rifampicin in prosthetic joint infections (PJI) caused by staphylococcus are currently unclear. Clindamycin is prescribed as dual therapy in this indication, and provides many advantages. We conducted a multicenter retrospective observational study evaluating the efficacy and safety of Clindamycin in prosthetic joint infections due to staphylococcus between January 2013 and December 2019.

Detailed Description

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Conditions

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Prosthetic Joint Infection Staphylococcus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Clindamycin and Rifampicin

Patients treated with Clindamycin and Rifampicin

No interventions assigned to this group

Clindamycin and Fluoroquinolone

Patients treated with Clindamycin and Fluoroquinolone

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with PJI defined according to the IDSA.
* Infection must be mono-microbial or multi-microbial with Staphylococcus spp sensitive to Clindamycin.
* Infection may be acute or chronic, nosocomial or community-acquired.
* Patient having received a curative treatment with Clindamycin.

Exclusion Criteria

* Patients with osteitis, osteomyelitis, septic arthritis in native joints, diabetic foot infections, spondylodiscitis, infections in external fixator, surgical site infections following neurosurgical management, bedsores, skin and soft tissue infections.
* Patients with mono-microbial infections other than Staphylococcus, multi-microbial infections including other bacteria than Staphylococcus, suspected Osteoarticular Infection without microbial identification.
* Patients with clindamycin-resistant Staphylococcal PJI, constitutive MLSb phenotype.
* Patients having received suspensive treatment with Clindamycin.
* Patients treated with Clindamycin as last line of treatment for a duration of less than 14 days.
* Patients refusing to participate
* Patients under legal protection (guardianship, curatorship, ..)
Minimum Eligible Age

18 Years

Maximum Eligible Age

120 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Brest

Brest, , France

Site Status

Countries

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France

Other Identifiers

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CISTA - 29BRC21.0123

Identifier Type: -

Identifier Source: org_study_id

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