Combining PAS to Non-invasive VNS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-01

Study Completion Date

2021-12-30

Brief Summary

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Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.

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Detailed Description

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Conditions

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Spinal Plasticity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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PAS and VNS

Group Type EXPERIMENTAL

PAS

Intervention Type DEVICE

Non-invasive vagus nerve stimulation delivered through cymba concha \& cymba cavum of the ear.

Intervention Type DEVICE

Eligibility Criteria

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Exclusion Criteria

* contraindications to TMS (e.g. brain pathology, implanted devices)
* contraindications to MRI (e.g. MRI incompatible implants)
* continuous use of CNS-active drugs
* neurological, psychiatric or cardiovascular disease
* drug abuse

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes