Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
312 participants
OBSERVATIONAL
2016-11-01
2024-12-01
Brief Summary
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The overall objective was to study the early development of osteoarthritis of the knee and its association with hand- and general osteoarthritis, metabolic diseases, biomarkers, long-term pain, physical function and stress patterns
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Detailed Description
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The project includes 4 different research areas that are studied with the help of several smaller sub-studies:
Research area 1: Metabolic osteoarthritis - to study the connections between metabolic factors and osteoarthritis development in the knee and hand.
A. Relationship between knee osteoarthritis and metabolic factors B. Relationship between osteoarthritis of the hand and metabolic factors Research area 2: Biomarkers in knee and hand osteoarthritis - to study cartilage and bone markers that reflect different processes in osteoarthritis development, e.g. inflammation, matrix degradation both in the short and long term Research area 3: Pain and osteoarthritis - to study pain development and pain pressure thresholds in relation to lifestyle, depression and health-related quality of life in individuals with symptomatic knee osteoarthritis Research area 4: Physical function and osteoarthritis - to study physical function, physical activity and measured stress patterns, as well as changes in stress patterns and the relationship between these and the development of osteoarthritis over time.
Study design This is a longitudinal cohort study including 306 individuals with knee pain in the southwest of Sweden, the Halland osteoarthritis (HALLOA) cohort. The enrolments took place from 2017-2019. The participants were recruited: 1) by primary health care clinics when searching care for knee pain, or 2) by advertisements in local newspapers. The inclusion criterions were current knee pain, aged 30-65 years, with no former known radiographic knee osteoarthritis (RKOA). the exclusion criterions were no cruciate ligament rupture or rheumatologic disorder. A general practitioner examined all participants to confirm the exclusion criteria.
The cohort will be followed for five years with yearly follow-ups.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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HALLOA
306 individuals with knee pain in the age between 30 and 65 years, without cruciate ligament injury
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
30 Years
65 Years
ALL
No
Sponsors
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The Swedish Rheumatism Ass
OTHER
FoU Center Spenshult
OTHER
Responsible Party
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Principal Investigators
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Maria LE Andersson, ass.prof.
Role: PRINCIPAL_INVESTIGATOR
FoU Spenshult
Locations
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Spenshult Research and Development center (FoU Spenshult)
Halmstad, , Sweden
Countries
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References
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Tornblom M, Haglund E, Bremander A, Nilsdotter A, Andersson ML, Hettiarachchi P, Johansson PJ, Svartengren M, Aili K. Associations between knee pain and knee-loading physical activities at work and leisure - a cross-sectional study based on accelerometer measurements. BMC Musculoskelet Disord. 2025 Apr 8;26(1):345. doi: 10.1186/s12891-025-08589-w.
Brogren E, Andersson M, Westenius M, Wittrup J, Zimmerman M. Associations between hand osteoarthritis, obesity and lipid metabolism: a cross-sectional study of the Halland County Osteoarthritis (HALLOA) cohort. BMC Musculoskelet Disord. 2024 Nov 22;25(1):944. doi: 10.1186/s12891-024-08073-x.
Tornblom M, Bremander A, Aili K, Andersson MLE, Nilsdotter A, Haglund E. Development of radiographic knee osteoarthritis and the associations to radiographic changes and baseline variables in individuals with knee pain: a 2-year longitudinal study. BMJ Open. 2024 Mar 8;14(3):e081999. doi: 10.1136/bmjopen-2023-081999.
Andersson MLE, Thoren E, Sylwander C, Bergman S. Associations between chronic widespread pain, pressure pain thresholds, leptin, and metabolic factors in individuals with knee pain. BMC Musculoskelet Disord. 2023 Aug 9;24(1):639. doi: 10.1186/s12891-023-06773-4.
Andersson M, Haglund E, Aili K, Bremander A, Bergman S. Associations between metabolic factors and radiographic knee osteoarthritis in early disease - a cross-sectional study of individuals with knee pain. BMC Musculoskelet Disord. 2022 Oct 28;23(1):938. doi: 10.1186/s12891-022-05881-x.
Andersson MLE, Haglund E, Aili K, Bremander A, Bergman S. Cohort profile: the Halland osteoarthritis (HALLOA) cohort-from knee pain to osteoarthritis: a longitudinal observational study in Sweden. BMJ Open. 2022 Jul 14;12(7):e057086. doi: 10.1136/bmjopen-2021-057086.
Related Links
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Study protocol
Other Identifiers
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HALLOA
Identifier Type: -
Identifier Source: org_study_id
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