Prediction of the Response to Neoadjuvant Radiation Chemotherapy Through Texture Analysis Derived From Medical Imaging

NCT ID: NCT04920435

Last Updated: 2021-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

124 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-02

Study Completion Date

2019-12-31

Brief Summary

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In patient with complete pathological response, surgery could be omitted without compromising progression-free or overall survival. A powerful prediction model is needed to guide management of this population.

Radiomics features provide complementary information about tumor heterogenity.

The aim of the investigators is to develop a model combining clinical and radiomic criteria able to predict complete pathological response.

Detailed Description

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Conditions

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Rectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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training population

patients from which we will develop the prediction model

No interventions assigned to this group

testing population

patients on whom we will test the prediction model

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* locally advanced rectal cancer
* patients who received concomitant radio-chemotherapy followed by surgery
* pre-therapeutic MRI and CT-scan dicom available

Exclusion Criteria

* age under 18 yo
* lack of MRI or CT-scan
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre Hospitalier de Cornouaille

Quimper, Brittany Region, France

Site Status

ICO

Nantes, Saint Herblain, France

Site Status

CHRU de Brest (Morvan)

Brest, , France

Site Status

Countries

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France

Other Identifiers

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RECTOMICS (29BRC20.0027)

Identifier Type: -

Identifier Source: org_study_id

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