Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes
NCT ID: NCT04907838
Last Updated: 2021-06-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
22 participants
INTERVENTIONAL
2018-05-01
2021-07-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Type 2 diabetics
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
Insulin clamp
Continous infusion insulin + glucose
BQ123
Continuous infusion of Insulin + glucose + BQ123
BQ123 + BQ788
Continous infusion of insulin + glucose + BQ123 + BQ788
Healthy controls
BQ123 (25 nmol/min), BQ788 (25 nmol/min)
Insulin clamp
Continous infusion insulin + glucose
BQ123
Continuous infusion of Insulin + glucose + BQ123
BQ123 + BQ788
Continous infusion of insulin + glucose + BQ123 + BQ788
Interventions
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Insulin clamp
Continous infusion insulin + glucose
BQ123
Continuous infusion of Insulin + glucose + BQ123
BQ123 + BQ788
Continous infusion of insulin + glucose + BQ123 + BQ788
Eligibility Criteria
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Inclusion Criteria
* BMI\<32
Exclusion Criteria
* pregnancy or birth within 3 month
* smoking
* Kidney disease
* beta-blockers
* insulin treatment (for type 2 diabetics)
40 Years
65 Years
ALL
Yes
Sponsors
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The University of Texas at Arlington
OTHER
University of Southern Denmark
OTHER
Responsible Party
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Stefan Mortensen
Professor
Principal Investigators
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Stefan Mortensen, DMSc
Role: PRINCIPAL_INVESTIGATOR
Professor
Locations
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Cardiovascular and Renal Research
Odense, , Denmark
Countries
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References
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Young BE, Padilla J, Finsen SH, Fadel PJ, Mortensen SP. Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake During Hyperinsulinemia in Type 2 Diabetes. Endocrinology. 2022 Mar 1;163(3):bqac008. doi: 10.1210/endocr/bqac008.
Other Identifiers
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s-20180040
Identifier Type: -
Identifier Source: org_study_id
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