Eosinophils in Human Adipose Tissue

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-08-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to better understand the interactions between the innate immune system, in particular eosinophils (EOS), and adipose tissue (AT) in human health and in disease states such as obesity and insulin resistance.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Endoscopic Gastric Mucosal Ablation as a Primary Obesity Therapy

NCT05486338

Obesity Adiposity

ACTIVE_NOT_RECRUITING NA

Influence of Central Obesity on the Esophageal Epithelial Barrier

NCT02776982

Gastroesophageal Reflux GERD

COMPLETED NA

Eon™ FR 1064 Full Abdomen Clinical Study Protocol

NCT04842110

Abdominal Obesity

COMPLETED NA

Contributing Factors in the Pathobiology of Airway Remodeling in Obesity

NCT03115632

Asthma Obesity Obesity, Morbid +1 more

COMPLETED

Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

NCT06339320

Endoscopic Sleeve Gastroplasty Obesity

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity Insulin Resistance

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Subjects with Obesity

Subjects will be recruited to undergo endoscopic sleeve gastroplasty. The subjects will be studied at baseline, 30, 60, 90 days after procedure

Group Type EXPERIMENTAL

endoscopy sleeve gastroplasty

Intervention Type PROCEDURE

endoscopic procedure for weight loss

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

endoscopy sleeve gastroplasty

endoscopic procedure for weight loss

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Obesity (BMI\>30 kg/m2).
* Evidence of insulin resistance as defined by hemoglobin A1c \> 5.7%.
* Mayo Clinic patients evaluated by Dr. Rahul Pannala.
* Pursue an endoscopic gastroplasty at Mayo Clinic Arizona in the Gastroenterology department.
* Equal distribution of gender.
* 18 yo older of age.
* BMI\>30 kg/m2.
* Nonsmoker.
* Taking no medication affecting glucose or lipid metabolism.
* No more than 5% change in body weight in the previous 6 months.
* Mostly sedentary (engaging in strenuous exercise (\> 70% max HR) less than 3 times a week).
* Not be receiving corticosteroid therapy.
* Have no history of asthma, COPD or atopic syndrome, or autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).

Exclusion Criteria

* \<17 years of age.
* BMI \<30 kg/m2.
* Smoker.
* Taking medication affecting glucose or lipid metabolism.
* Greater than 5% change in body weight within the previous six months.
* Engage in strenuous exercise (\>70% max HR) less than 3 times a week.
* Receiving corticosteroid therapy.
* Have a history of asthma.
* History of COPD or atopic syndrome.
* History of autoimmune disease (Ulcerative colitis, Chron's disease, eosinophilic esophagitis, any rheumatologic disease such as lupus, rheumatoid arthritis, Sjogren syndrome).

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No