Coronavirus Associated Pneumomediastinum and Pneumothorax
NCT ID: NCT04897152
Last Updated: 2022-04-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
241 participants
OBSERVATIONAL
2021-08-15
2021-08-31
Brief Summary
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PMS and PNX are rare complications of several lung infections such as Pneumocystis Jirovecii pneumonia, tuberculosis, bacterial necrotizing pneumonia, and herpes pneumonia.
However, an increasing number of PMS and PNX has been described in patients with SARS-CoV2 interstitial pneumonia. PMS and PNX can either present as the onset manifestation of COVID-19 disease, or occur as complications of non-invasive and/or invasive ventilation, or following to cystic and/or fibrotic evolution of the pathology.
The frequency of PMS and PNX during COVID-19 is not well defined, as the available data are limited to case collections and single reports. According to currently available scientific literature, PNX in COVID-19 occurs with frequency rates of 1-3%, up to 6% in patients undergoing non-invasive ventilation (NIV) and mechanical artificial ventilation (VAM). In McGuinness's analysis, which compared the complications of barotrauma in patients with acute respiratory distress syndrome (ARDS) in VAM, PNX and PMS occurred with frequency rates of 9% and 10%, respectively, while in non-COVID-19 population, PNX and PMS frequency rates were 12% and 3%, respectively.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
99 Years
ALL
No
Sponsors
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Azienda Sanitaria-Universitaria Integrata di Udine
OTHER
Responsible Party
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Luigi Vetrugno
Clinical Professor in Anesthesiology and Intensive Care
Locations
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Policlinico S.Orsola-Malpighi, Pneumologia e Terapia Intensiva Respiratoria
Bologna, , Italy
Policlinico S.Orsola-Malpighi, U.O Malattie Infettive
Bologna, , Italy
Azienda Ospedaliero-Universitaria V.Emanuele Ferrarotto, S.bambino, Malattie Infettive
Catania, , Italy
Azienda Ospedaliero-Universitaria V.Emanuele Ferrarotto, S.bambino, U.O.C. di Malattie Infettive
Catania, , Italy
Azienda Ospedaliera S.Croce e Carle Cuneo, SC Malattie Infettive e tropicali,
Cuneo, , Italy
Ospedale Policlinico San Martino-IRCCS, Clinica di Malattie Infettive e Tropicali
Genova, , Italy
Fondazione IRCCS, Ca Granda Ospedale Maggiore Policlinico, UOC, Malattie Infettive
Milan, , Italy
Ospedale dei colli, Malattie Infettive ed Urgenze Infettivologiche,
Napoli, , Italy
Azienda Ospedaliera di Padova, S.C di Fisiopatologia respiratoria,
Padua, , Italy
Unità Operativa Complessa Istituto di Anestesia e Rianimazione dell'Azienda Ospedale-Università di Padova,
Padua, , Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone di Palermo, UOC Anestesia Rianimazione con Terapia Intensiva Polivalente e del Dolore
Palermo, , Italy
Azienda Ospedaliero-Universitaria di Parma, Clinica Pneumologica
Parma, , Italy
Azienda Ospedaliera Perugia, Malattie Infettive
Perugia, , Italy
Azienda USL Toscana Ovest, Ospedale Felice Lotti SOC Medicina Interna
Pontedera, , Italy
Azienda Sanitaria Universitaria Friuli Occidentale, S.C Pneumologia
Pordenone, , Italy
AOU Città della Salute e Scienza, SC Malattie Infettive
Torino, , Italy
Azienda Ospedaliera Ordine Mauriziano S.C. Pneumologia e Unità di Terapia Semi Intensiva Respiratoria
Torino, , Italy
Ospedale Cardinal Massaia, SC Malattie Infettive
Torino, , Italy
Azienda Sanitaria Universitaria Giuliano Isontina, S.C Pneumologia
Trieste, , Italy
Anesthesiology and Intensive Care Clinic - Department of Medicine - ASUIUD
Udine, , Italy
Azienda ospedaliero universitaria Friuli Centrale, Anestesia e Rianimazione 1
Udine, , Italy
Azienda ospedaliero universitaria Friuli Centrale, Anestesia e Rianimazione 2
Udine, , Italy
Azienda ospedaliero universitaria Friuli Centrale, Clinica di Anestesia e Rianimazione
Udine, , Italy
Azienda Ospedaliero Universitaria Friuli Centrale, Malattie infettive
Udine, , Italy
Azienda Ospedaliero Universitaria Friuli Centrale, Pneumologia
Udine, , Italy
Azienda Sanitaria locale di Vercelli, Malattie infettive
Vercelli, , Italy
Università di Verona, Clinica delle Malattie Infettive e Tropicali
Verona, , Italy
Countries
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References
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Maunder RJ, Pierson DJ, Hudson LD. Subcutaneous and mediastinal emphysema. Pathophysiology, diagnosis, and management. Arch Intern Med. 1984 Jul;144(7):1447-53.
Wang W, Gao R, Zheng Y, Jiang L. COVID-19 with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema. J Travel Med. 2020 Aug 20;27(5):taaa062. doi: 10.1093/jtm/taaa062.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
Yao W, Wang T, Jiang B, Gao F, Wang L, Zheng H, Xiao W, Yao S, Mei W, Chen X, Luo A, Sun L, Cook T, Behringer E, Huitink JM, Wong DT, Lane-Fall M, McNarry AF, McGuire B, Higgs A, Shah A, Patel A, Zuo M, Ma W, Xue Z, Zhang LM, Li W, Wang Y, Hagberg C, O'Sullivan EP, Fleisher LA, Wei H; collaborators. Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations. Br J Anaesth. 2020 Jul;125(1):e28-e37. doi: 10.1016/j.bja.2020.03.026. Epub 2020 Apr 10.
McGuinness G, Zhan C, Rosenberg N, Azour L, Wickstrom M, Mason DM, Thomas KM, Moore WH. Increased Incidence of Barotrauma in Patients with COVID-19 on Invasive Mechanical Ventilation. Radiology. 2020 Nov;297(2):E252-E262. doi: 10.1148/radiol.2020202352. Epub 2020 Jul 2.
Vetrugno L, Castaldo N, Fantin A, Deana C, Cortegiani A, Longhini F, Forfori F, Cammarota G, Grieco DL, Isola M, Navalesi P, Maggiore SM, Bassetti M, Chetta A, Confalonieri M, De Martino M, Ferrari G, Francisi D, Luzzati R, Meini S, Scozzafava M, Sozio E, Tascini C, Bassi F, Patruno V; Italian COVI-MIX Study Group; De Robertis E, Aldieri C, Ball L, Baratella E, Bartoletti M, Boscolo A, Burgazzi B, Catalanotti V, Confalonieri P, Corcione S, De Rosa FG, De Simoni A, Bono VD, Tria RD, Forlani S, Giacobbe DR, Granozzi B, Labate L, Lococo S, Lupia T, Matellon C, Mehrabi S, Morosi S, Mongodi S, Mura M, Nava S, Pol R, Pettenuzzo T, Quyen NH, Rescigno C, Righi E, Ruaro B, Salton F, Scabini S, Scarda A, Sibani M, Tacconelli E, Tartaglione G, Tazza B, Vania E, Viale P, Vianello A, Visentin A, Zuccon U, Meroi F, Buonsenso D. Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study). Pulmonology. 2023 Nov-Dec;29(6):457-468. doi: 10.1016/j.pulmoe.2022.11.002. Epub 2022 Nov 24.
Other Identifiers
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COVI-MIX
Identifier Type: -
Identifier Source: org_study_id
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