The Effects of Caffeine on Human Spinal Motoneurons

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-03-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study evaluates the effects of orally ingested, commercially available, coffee (3 mg/kg of caffeine) on the excitability of human spinal motoneurons of the lower leg.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI

NCT06763172

Healthy Caffeine Adenosine +1 more

RECRUITING PHASE4

Theanine and Caffeine on Neurophysiology of Attention

NCT02770105

L-theanine

COMPLETED NA

Modulation of Spontaneous Cortical Activity by tDCS: BRAIN Initiative I

NCT03672747

Brain Function

COMPLETED NA

Is Caffeine an Environmental Modifier in Huntington's Disease?

NCT03034122

Huntington Disease

COMPLETED

Cerebral Blood Flow and tDCS

NCT04033133

Multiple Sclerosis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Recently, it has been shown that human spinal motoneurons do not simply act as a binary control system. Instead, they are regulated by intrinsic properties that can elicit lingering effects on the descending motoneuron. Caffeine, one of the world's most popular over-the-counter supplements, can potentially augment these characteristics of motoneurons. Using decomposition software and non-invasive, high-density surface electromyography, it is possible to extract the characteristics of these motoneurons. This project will utilize a double-blind, inactive-placebo controlled, crossover design study to examine and quantify the effects of caffeine on motoneuron excitability.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Healthy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Caffeine

Single-dose, orally ingested, instant coffee.

Group Type EXPERIMENTAL

Coffee

Intervention Type DIETARY_SUPPLEMENT

Starbucks brand "Via" instant coffee. (Caffeine Content: 3 mg / kg)

Inactive Placebo

Single-dose, orally ingested, instant decaffeinated coffee (equal weight to intervention dose).

Group Type PLACEBO_COMPARATOR

Decaffeinated coffee

Intervention Type DIETARY_SUPPLEMENT

Starbucks brand "Via" instant decaffeinated coffee. (Caffeine Content: 15 - 25 mg)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Coffee

Starbucks brand "Via" instant coffee. (Caffeine Content: 3 mg / kg)

Intervention Type DIETARY_SUPPLEMENT

Decaffeinated coffee

Starbucks brand "Via" instant decaffeinated coffee. (Caffeine Content: 15 - 25 mg)

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

● Between 18 and 70 years of age

Exclusion Criteria

* Significant neurological or orthopedic injuries, which may limit volitional torque generation in the tested muscles.
* Significant change in the subjects' health or treatment in the past month.
* Known history of cardiovascular pathology (to include: uncontrolled hypertension, cardiac arrhythmias) or medical restrictions to caffeine ingestion.
* Allergies or dislike of coffee.
* Women who are pregnant will be excluded due to potential forces at trunk from pelvic safety harness and due to potential adverse effects of caffeine on the developing child.
* Women who are breastfeeding will be excluded due potential adverse effects on the breastfeeding infant from caffeine administration.
* Adults unable to consent, minors, pregnant women, and prisoners will not be included.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes