Calibration of a Wrist Cuff Blood Pressure Device, According to the AAMI/ESH/ISO Universal Standard

NCT ID: NCT04869826

Last Updated: 2023-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-15

Study Completion Date

2023-12-31

Brief Summary

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The objective of this study is to calibrate the blood pressure measurements of the Pulsewave Health Monitor (PAD-2A) device to be within 5±8 mmHg of the average of the dual-observer measurements via an aneroid sphygmomanometer (reference device), as per the methodology described in the ISO 81060-2: AMD\_2020 protocol.

Detailed Description

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The plan for this study is to calibrate the blood pressure measurements of the PAD-2A device with the dual-observer blood pressure measurements via an aneroid sphygmomanometer (reference device), as per the ISO 81060-2: AMD\_2020 protocol. The data will be collected and analyzed in order to calibrate the PAD-2A device blood pressure measurements to be within 5±8 mmHg of the average of the dual-observer auscultatory blood pressure measurements by adjusting the device algorithm.

Conditions

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Hypertension

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Outpatients Complicated Hypertension Clinic

This study population consists of approximately 200 adult male and female participants (≥ 19 years of age; minimum 30% male/female). Participants will be recruited from eligible patients who are referred to the Complicated Hypertension Clinic at the Saint John Regional Hospital (SJRH) as well as non-patient participants who are willing to volunteer to consent to participate in the study.

Pulsewave Health Monitor (PAD-2A) Device

Intervention Type DEVICE

This is an observational, comparison study of blood pressure measurements. The objective of this study is to calibrate the blood pressure measurements of the Pulsewave Health Monitor (PAD-2A) device to be within 5±8 mmHg of the average of the dual-observer auscultatory blood pressure measurements via an aneroid sphygmomanometer (reference device), as per the ISO 81060-2: AMD\_2020 universal protocol.

Interventions

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Pulsewave Health Monitor (PAD-2A) Device

This is an observational, comparison study of blood pressure measurements. The objective of this study is to calibrate the blood pressure measurements of the Pulsewave Health Monitor (PAD-2A) device to be within 5±8 mmHg of the average of the dual-observer auscultatory blood pressure measurements via an aneroid sphygmomanometer (reference device), as per the ISO 81060-2: AMD\_2020 universal protocol.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adults ≥ 19 years of age (minimum 30% male/female)
* Wrist circumference between 13.5 cm. - 23 cm. (5.3 in. - 9.1 in.):

Specifically for this test device, the wrist size of the consented participants will be distributed accordingly for a Gaussian distribution:

Lowest Octile: ≥ 13.5cm to \< 14.7cm Lower Quarter: ≥ 13.5cm to \< 15.9cm Lower-Middle Quarter: ≥ 15.9cm to \< 18.3cm Upper-Middle Quarter: ≥ 18.3cm to \< 20.7cm Upper Quarter: ≥ 20.7cm to ≤ 23.0cm Highest Octile: ≥ 21.9cm to ≤ 23.0cm

● Willing to volunteer to participate and to sign the study specific informed consent form

Exclusion Criteria

* Wrist circumference less than 13.5 cm. (5.3 in.) or greater than 23 cm. (9.1 in)
* Hand or body tremors
* Irregular heart rhythm (bigeminy, trigeminy, isolated ventricular premature beat (VPB), atrial fibrillation)
* Korotkoff sound K5 not audible
* Pregnant
* A musculoskeletal disorder that prevents a non-invasive device to be inflated/deflated on the arm
* Unwilling to volunteer to participate and to sign the study specific informed consent form
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cloud DX Inc.

INDUSTRY

Sponsor Role collaborator

Horizon Health Network

OTHER

Sponsor Role collaborator

New Brunswick Health Research Foundation

OTHER

Sponsor Role collaborator

Dalhousie University

OTHER

Sponsor Role collaborator

Cardiovascular Research New Brunswick

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Martin MacKinnon, MD, FRCP(C)

Role: PRINCIPAL_INVESTIGATOR

Complicated Hypertension Clinic, Saint John Regional Hospital

Locations

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Horizon Health Network

Saint John, , Canada

Site Status RECRUITING

Countries

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Canada

Central Contacts

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Christie Aguiar, PhD

Role: CONTACT

506-977-2712

Keith R. Brunt, PhD

Role: CONTACT

506-636-6974

Related Links

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https://clouddx.com/

Cloud DX device company website.

Other Identifiers

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STP-PW2-002

Identifier Type: OTHER

Identifier Source: secondary_id

RS#: 2021-3003; R#: 101246

Identifier Type: -

Identifier Source: org_study_id

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