Combating Alzheimer's Through Sleep and Exercise

NCT ID: NCT04855630

Last Updated: 2025-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-01

Study Completion Date

2026-03-01

Brief Summary

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The purpose of this research is to see how sleep and exercise affects dementia risk over time.

Detailed Description

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Conditions

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Alzheimer Disease Dementia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Sleep Only Group

Participants in this group will wear the DREEM 2 headband for 12 weeks.

Group Type EXPERIMENTAL

DREEM 2 Headband

Intervention Type DEVICE

Participants will wear the DREEM 2 headband for 3 months for a minimum of 4 out of 7 nights per week and will participate in its digital therapeutic Cognitive Behavioral Therapy - Insomnia (CBT-I) intervention (entails brain stimulation to improve slow wave sleep and sleep hygiene counseling tips to improve sleep behaviors).

Exercise Only Group

Participants in this group will workout twice a week for 12 weeks.

Group Type ACTIVE_COMPARATOR

Exercise Routine

Intervention Type OTHER

Participants will partake in a guided exercise routine. Each routine consists of 30-minute mild circuit training session twice per week for 3 months.

Exercise and Sleep Group

Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.

Group Type ACTIVE_COMPARATOR

DREEM 2 Headband

Intervention Type DEVICE

Participants will wear the DREEM 2 headband for 3 months for a minimum of 4 out of 7 nights per week and will participate in its digital therapeutic Cognitive Behavioral Therapy - Insomnia (CBT-I) intervention (entails brain stimulation to improve slow wave sleep and sleep hygiene counseling tips to improve sleep behaviors).

Exercise Routine

Intervention Type OTHER

Participants will partake in a guided exercise routine. Each routine consists of 30-minute mild circuit training session twice per week for 3 months.

Interventions

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DREEM 2 Headband

Participants will wear the DREEM 2 headband for 3 months for a minimum of 4 out of 7 nights per week and will participate in its digital therapeutic Cognitive Behavioral Therapy - Insomnia (CBT-I) intervention (entails brain stimulation to improve slow wave sleep and sleep hygiene counseling tips to improve sleep behaviors).

Intervention Type DEVICE

Exercise Routine

Participants will partake in a guided exercise routine. Each routine consists of 30-minute mild circuit training session twice per week for 3 months.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Able to perform mild exercise
2. Able to wear DREEM 2 Headband
3. Able to wear a Fitbit wrist watch
4. Able to perform the Everlywell biomarker procedure
5. Able to Understand and Speak English
6. Able to operate a digital device like mobile phone, iPad, or computer
7. Self-reported history of problems with cognitive impairment: memory, concentration, and processing information
8. Only participants cognitively able and willing to provide consent will be included.

Exclusion Criteria

1. Prohibited from or unable to perform mild exercise
2. Unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason
3. Unable to speak or understand English
4. Unable to use mobile device/smartphone technology
5. Unable or unwilling to consent for any reason.
Minimum Eligible Age

45 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shipley Foundation

UNKNOWN

Sponsor Role collaborator

Dreem

INDUSTRY

Sponsor Role collaborator

University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Azizi Seixas

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Azizi A Seixas, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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University of Miami Hospitals

Miami, Florida, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Azizi A Seixas, PhD

Role: CONTACT

3052431301

Debbie Chung, PhD

Role: CONTACT

3052431301

Facility Contacts

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Debbie Chung, PhD

Role: primary

3052431301

Azizi A Seixas, PhD

Role: backup

3052431301

Other Identifiers

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20-01023

Identifier Type: OTHER

Identifier Source: secondary_id

20220931

Identifier Type: -

Identifier Source: org_study_id

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