Postoperative VEGF and Recurrence After Colon Cancer Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

280 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2021-12-31

Brief Summary

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The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the tumor recurrence in patients with colon cancer operated with a curative intention.

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Detailed Description

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DESIGN: Prospective multicentric study.

PARTICIPATION: Colorectal Surgery Units of Hospital del Mar, Barcelona; Hospital Universitari Joan XXIII, Tarragona; Hospital Universitari La Fe, Valencia; Hospital Clínico San Carlos, Madrid; Hospital General de Granollers, Granollers; Hospital Germans Trias i Pujol, Badalona; Athalaia, Xarxa Assistencial Universitària de Manresa, Manresa

STUDY SUBJECTS: 280 consecutive patients with non-metastatic colon cancer in whom a curative intent resection is performed.

DETERMINATIONS: Determination of the proangiogenic cytokine VEGF in serum on the postoperative day four to assess its relationship with oncological results on long-term follow-up.

Conditions

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Angiogenesis Colon Cancer Surgery Recurrence VEGF Overexpression

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients after surgery for colon cancer with intention to cure

Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study, who will undergo elective surgical resection with potentially curative intention

Surgery for colon cancer with intention to cure

Intervention Type PROCEDURE

Surgery by open or laparoscopic approach

Interventions

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Surgery for colon cancer with intention to cure

Surgery by open or laparoscopic approach

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with colon cancer admitted to the Colorectal Surgery Unit of the centers participating in the study,
* Patients who will undergo elective surgical resection with potentially curative intention

Exclusion Criteria

* Patients with metastatic disease
* Patients with synchronous colon neoplasia or in the previous five years
* Patients undergoing emergency surgery
* Patients who do not sign the informed consent.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No