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Impact of Vascular Resection on Survival and Postoperative Outcomes in Patients With Hilar Cholangiocarcinoma: A Retrospective Study

NCT ID: NCT07311798

Last Updated: 2025-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-12-31

Study Completion Date

2026-02-28

Brief Summary

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Hilar cholangiocarcinoma is a highly aggressive malignancy, and surgical resection remains the only potentially curative treatment. Due to the frequent involvement of major vascular structures, vascular resection is increasingly performed to achieve negative surgical margins; however, its impact on survival and postoperative outcomes remains controversial. This retrospective study aims to evaluate the association between vascular resection and clinical outcomes, including survival and postoperative outcomes, in patients with hilar cholangiocarcinoma undergoing curative-intent surgery.

Detailed Description

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Conditions

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Cholangiocarcinoma, Hilar

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Vascular Resection Group

Patients with hilar cholangiocarcinoma who underwent curative-intent surgery with concomitant vascular resection, including portal vein and/or hepatic artery resection.

No Intervention: Observational Cohort

Intervention Type OTHER

This is an observational study. No intervention is assigned.

Non-Vascular Resection Group

Patients with hilar cholangiocarcinoma who underwent curative-intent surgery without vascular resection.

No Intervention: Observational Cohort

Intervention Type OTHER

This is an observational study. No intervention is assigned.

Interventions

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No Intervention: Observational Cohort

This is an observational study. No intervention is assigned.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent surgical treatment at the Department of Hepatobiliary and Pancreatic Surgery of our hospital between January 2010 and December 2024, including those with or without concomitant vascular resection.
* Pathologically confirmed diagnosis of hilar cholangiocarcinoma after surgery.
* Complete clinical and follow-up data available for outcome analysis.

Exclusion Criteria

* Patients with distant metastasis or who underwent only palliative or exploratory surgery.
* Patients diagnosed preoperatively or intraoperatively with other types of biliary malignancies not located at the hilar region.
* Patients with incomplete medical records or missing key clinical or follow-up data.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yongjun Chen

OTHER

Sponsor Role lead

Responsible Party

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Yongjun Chen

Director

Responsibility Role SPONSOR_INVESTIGATOR

Other Identifiers

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BTC-002

Identifier Type: -

Identifier Source: org_study_id