Acute Salt Sensitivity of Blood Pressure

NCT ID: NCT04844255

Last Updated: 2021-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

132 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-01

Study Completion Date

2021-02-28

Brief Summary

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Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.

Detailed Description

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Conditions

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Blood Pressure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Time series design
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Pre and post intervention group

Same individuals are examined before and after taking 2 tablets of salt

Group Type OTHER

dietary salt

Intervention Type DIETARY_SUPPLEMENT

2 grams of dietary salt

Interventions

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dietary salt

2 grams of dietary salt

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study)

Exclusion Criteria

* diabetes patients, ill participants
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zambia

OTHER

Sponsor Role collaborator

Mulungushi University

OTHER

Sponsor Role lead

Responsible Party

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Sepiso K. Masenga

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sepiso K Masenga, PhD

Role: PRINCIPAL_INVESTIGATOR

Mulungushi University

Locations

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Livingstone Central Hospital

Livingstone, Southern Province, Zambia

Site Status

Countries

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Zambia

References

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Masenga SK, Hamooya BM, Patel KP, Kirabo A. Erythrocyte glycocalyx sensitivity to sodium is associated with salt sensitivity of blood pressure in women but not men. Front Nutr. 2024 Mar 8;11:1334853. doi: 10.3389/fnut.2024.1334853. eCollection 2024.

Reference Type DERIVED
PMID: 38524849 (View on PubMed)

Other Identifiers

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PACTR202102852000433

Identifier Type: -

Identifier Source: org_study_id

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