The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Essential Hypertension

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-05-31

Study Completion Date

2009-08-31

Brief Summary

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The aim of the study is to test the following hypotheses:

* that the function and/or regulation of AQP2 and/or ENaC in the principal cells is abnormal in essential hypertension.
* if an abnormal function of the principal cells is present in essential hypertension, this will become more pronounced at high and low sodium intake.

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Detailed Description

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Conditions

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Essential Hypertension and Healthy Controls

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Interventions

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high sodium diet

250-350 mmol

Intervention Type BEHAVIORAL

Low Sodium Diet

25-35 mmol

Intervention Type BEHAVIORAL

Other Intervention Names

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For four days For four days

Eligibility Criteria

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Inclusion Criteria

* Caucasian men and women
* Age 18-65 years
* Arterial hypertension
* Body mass index between 18.5 and 30 kg/m2

Exclusion Criteria

* Secondary hypertension
* Isolated systolic hypertension
* History or clinical signs of AMI, atrial fibrillation, disease of the heart valves, or chronic heart failure.
* Malignant disease
* Prior apoplexy
* alcohol or drug abuse
* Drug use except antihypertensives and oral contraceptives
* Abnormal biochemical screening of the blood regarding: red and white blood count, s-creatinine (\> 200 micromol/L), b-hemoglobin, p-Sodium, p- potassium, p-albumine, p-bilirubin, p-alanine aminotransferase, p-alkaline phosphatase, p-cholesterol and b-glucose.
* Abnormal screening of the urine regarding: Blood, albumine and glucose.
* abnormal electrocardiogram
* Blood donation within one month of the first examination day
* Unwillingness to participate

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes