Hemp Seed Awareness

NCT ID: NCT04841954

Last Updated: 2024-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-01

Study Completion Date

2025-05-31

Brief Summary

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Hemp is a plant of the Cannabaceae family. Cannabis sativa, derived from female flowers, is the first illicit substance used by adolescents and is a major public health problem. Its psycho-active effects come from tetrahydrocannabinol (THC).

Unlike recreational cannabis, industrial hemp derived from cannabis sativa has a high level of cannabidiol (CBD) but a negligible level of tetrahydrocannabinol. Its seeds are now consumed in various forms and generate increasing interest. Seeds have many nutritional benefits.

It seems important to take an interest in hemp, given the recent expansion of medical cannabis and the increasing use of cannabis for recreational purposes. It is incriminated in various allergies (contact dermatitis, asthma, rhinoconjunctivitis) but also in the occurrence of anaphylaxis to certain foods by cross-allergy in atopic subjects, in association with an Lipid-Transfer Proteins (LTP protein), present in the flower of Cannabis sativa.

Unlike the allergy to recreational cannabis, the allergenicity of hemp seeds is little studied.

Hemp seed can cause severe anaphylactic reactions. In all reported cases, the prick-tests were positive for the seeds. Often, patients had never been in contact with hemp seeds but had already been exposed to cannabis by respiratory or manual routes.

The investigators hypothesize that sensitization by the skin or respiratory route (cannabis smokers, passive exposure to cannabis, workers exposed to hemp, etc.) could lead to the development of a food allergy to hemp seed.

Detailed Description

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Conditions

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Allergy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Prick-test

Group Type EXPERIMENTAL

hemp prick-test

Intervention Type DIAGNOSTIC_TEST

hemp seed and flower prick-test

Interventions

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hemp prick-test

hemp seed and flower prick-test

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Major patient
* Patient referred to the Allergology Unit of the Hospital of Angers, in consultation or in Hospitalization - for conducting prick-tests
* Patient affiliated or beneficiary of a social security scheme
* Patient with informed consent

Exclusion Criteria

* Pregnant women, parturients
* Persons deprived of liberty by administrative or judicial decision
* Persons receiving psychiatric care under duress
* Adults under legal protection measure
* People out of state to express consent
* people not able to understand French language
* Patients whose skin reactivity prevents interpretation of tests (patients who cannot interrupt anti-histamines or have severe eczema)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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MORISSET Martine

Angers, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Martine MORISSET

Role: CONTACT

0241353637 ext. +33

DRCI Promotion Interne

Role: CONTACT

0241353637 ext. +33

Facility Contacts

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Martine MORISSET, Dr

Role: primary

2 41 35 47 49 ext. +33

Other Identifiers

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49RC21_0048

Identifier Type: -

Identifier Source: org_study_id

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