Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

NCT ID: NCT04835545

Last Updated: 2022-07-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 13 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-03-29
• Study Completion Date: 2024-04-01

Brief Summary

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Detailed Description

The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.

Conditions

Accident Caused by Snow Avalanche

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Wet Perlite, 2L air pocket

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with 2L air pocket

Group Type: EXPERIMENTAL

extreme hypercapnia induced by ventilation insufficiency

Intervention Type: OTHER

extreme hypercapnia

Wet Perlite 2L air pocket with resistance compensation

Breathing in the simulated avalanche snow. Breathing into model of wet perlite 2L air pocket with resistance compensation

Group Type: EXPERIMENTAL

extreme hypercapnia induced by ventilation insufficiency

Intervention Type: OTHER

extreme hypercapnia

Wet Perlite, no air pocket

Breathing in the simulated avalanche snow. Breathing into model of wet perlite with no air pocket

Group Type: EXPERIMENTAL

extreme hypercapnia induced by ventilation insufficiency

Intervention Type: OTHER

extreme hypercapnia

Interventions

extreme hypercapnia induced by ventilation insufficiency

extreme hypercapnia

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

Exclusion Criteria

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Czech Technical University in Prague

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Karel Roubík, PhD

Role: STUDY_DIRECTOR

Czech Technical University in Prague, FBMI

Locations

Czech Technical University, Faculty of Biomedical Engineering

Kladno, , Czechia

Countries

Czechia

References

Roubik K, Sieger L, Sykora K. Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study. PLoS One. 2015 Dec 14;10(12):e0144332. doi: 10.1371/journal.pone.0144332. eCollection 2015.

Reference Type: BACKGROUND

PMID: 26666523 (View on PubMed)

Other Identifiers

DP-2021-Nemec

Identifier Type: -

Identifier Source: org_study_id