Effectiveness of Ambu® aScope™ 4 Cysto With the aView™ 2 Advance for Flexible Cystoscopy

NCT ID: NCT04829461

Last Updated: 2022-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-27

Study Completion Date

2022-07-20

Brief Summary

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The purpose of this study is to evaluate the use of the single-use Ambu® aScope™ 4 Cysto for removal of ureteral stents as compared to routine flexible reusable cystoscopes.

Detailed Description

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This study is a prospective, randomized, multi-center, post-market investigation of the effectiveness of Ambu® aScope™ 4 Cysto (single-use cystoscope) as compared to routine flexible reusable cystoscopes (standard of care) for ureteral stent removals. The investigation will include approximately 102 subjects (randomized at a 1:1 ratio).

Conditions

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Cystoscopy Ureteral Stent

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ambu® aScope™ 4 Cysto

Ureteral stent removal procedure performed with Ambu® aScope™ 4 Cysto (single-use cystoscope).

Group Type EXPERIMENTAL

Ambu® aScope™ 4 Cysto with the aView™ 2 Advance used for stent removal

Intervention Type DEVICE

Procedure using a single-use cystoscope for stent removal

Standard of Care (SOC)

Ureteral stent removal procedure performed with standard of care (reusable cystoscope).

Group Type ACTIVE_COMPARATOR

Standard of care reusable cystoscope used for stent removal

Intervention Type DEVICE

Procedure using a reusable cystoscope for stent removal

Interventions

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Ambu® aScope™ 4 Cysto with the aView™ 2 Advance used for stent removal

Procedure using a single-use cystoscope for stent removal

Intervention Type DEVICE

Standard of care reusable cystoscope used for stent removal

Procedure using a reusable cystoscope for stent removal

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Adult (male or female), ≥18 years old
2. Patient undergoing routine flexible cystoscopy
3. Patient with a ureteral stent in the urinary system that is ready to be removed.
4. No active urinary tract infection
5. Subject is willing and able to sign informed consent and HIPAA authorization and comply with requirements of the protocol.

Exclusion Criteria

1. History of prior bladder/urethral reconstructive surgery.
2. History of high-grade bladder cancer or carcinoma in-situ of the bladder, undergoing cystoscopy for follow-up/surveillance purposes.
3. Known unpassable urethral stricture
4. Febrile patient with active urinary tract infection (UTI)
5. Subjects with acute infection (acute urethritis, acute prostatitis, acute epididymitis)
6. Subject with severe coagulopathy
7. Patient is unable to read and/or understand study requirements
8. Patient is unable or unwilling to provide written consent to participate in the study.
9. Subject, in the opinion of the Investigator, has a severe comorbidity, poor general physical/mental health and/or a condition that will not
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ambu A/S

INDUSTRY

Sponsor Role collaborator

Ambu Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elizabeth Smith

Role: STUDY_DIRECTOR

Ambu Inc.

Locations

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The Pennsylvania State University and The Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status

University of Wisconsin-Madison

Madison, Wisconsin, United States

Site Status

Countries

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United States

References

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Samplaski MK, Jones JS. Two centuries of cystoscopy: the development of imaging, instrumentation and synergistic technologies. BJU Int. 2009 Jan;103(2):154-8. doi: 10.1111/j.1464-410X.2008.08244.x. Epub 2008 Dec 8.

Reference Type BACKGROUND
PMID: 19076146 (View on PubMed)

O'Sullivan DC, Chilton CP. Flexible cystoscopy. Br J Hosp Med. 1994 Apr 6-19;51(7):340-5.

Reference Type BACKGROUND
PMID: 8081563 (View on PubMed)

Pillai PL, Sooriakumaran P. Flexible cystoscopy: a revolution in urological practice. Br J Hosp Med (Lond). 2009 Oct;70(10):583-5. doi: 10.12968/hmed.2009.70.10.44626.

Reference Type BACKGROUND
PMID: 19966704 (View on PubMed)

Gee JR, Waterman BJ, Jarrard DF, Hedican SP, Bruskewitz RC, Nakada SY. Flexible and rigid cystoscopy in women. JSLS. 2009 Apr-Jun;13(2):135-8.

Reference Type BACKGROUND
PMID: 19660204 (View on PubMed)

Kadi N, Menezes P. ABC of flexible cystoscopy for junior trainee and general practitioner. Int J Gen Med. 2011;4:593-6. doi: 10.2147/IJGM.S20267. Epub 2011 Aug 19.

Reference Type BACKGROUND
PMID: 21887113 (View on PubMed)

Miner N, Harris V, Lukomski N, Ebron T. Rinsability of orthophthalaldehyde from endoscopes. Diagn Ther Endosc. 2012;2012:853781. doi: 10.1155/2012/853781. Epub 2012 May 16.

Reference Type BACKGROUND
PMID: 22665966 (View on PubMed)

Sokol WN. Nine episodes of anaphylaxis following cystoscopy caused by Cidex OPA (ortho-phthalaldehyde) high-level disinfectant in 4 patients after cytoscopy. J Allergy Clin Immunol. 2004 Aug;114(2):392-7. doi: 10.1016/j.jaci.2004.04.031.

Reference Type BACKGROUND
PMID: 15316522 (View on PubMed)

Johnson BA, Raman JD, Best SL, Lotan Y. Prospective Randomized Trial of Single-Use vs Reusable Cystoscope for Ureteral Stent Removal. J Endourol. 2023 Oct;37(10):1139-1144. doi: 10.1089/end.2023.0134.

Reference Type DERIVED
PMID: 37565290 (View on PubMed)

Other Identifiers

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CIS-023

Identifier Type: -

Identifier Source: org_study_id

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