Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-08

Study Completion Date

2025-09-08

Brief Summary

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Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.

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Detailed Description

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Conditions

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Anorexia Nervosa

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Without adapted physical activity program (APA)

Group Type ACTIVE_COMPARATOR

physical activity program (APA)

Intervention Type OTHER

adapted physical activity program (APA)

With adapted physical activity program (APA)

Group Type EXPERIMENTAL

physical activity program (APA)

Intervention Type OTHER

adapted physical activity program (APA)

Interventions

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physical activity program (APA)

adapted physical activity program (APA)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Female
2. Patient \> 18 years
3. Follow-up in the department of clinical Nutrition of Rouen
4. BMI ≥15,0 and \<18,5 kg/m²
5. Diagnosis of anorexia nervosa according to DSM-V classification

Exclusion Criteria

1. Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension
2. Patients with poor understanding of spoken or written French
3. Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults
4. Person subject to a safeguard of justice, guardianship or curatorship.
5. Pregnant or breastfeeding woman

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No