Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery

NCT ID: NCT04807621

Last Updated: 2021-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-14

Study Completion Date

2022-08-31

Brief Summary

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The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital heart defects.

Detailed Description

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Conditions

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Congenital Heart Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Platelets

Patients recieve, in the presence of significant bleeding and pathological results of ROTEM analysis, a platelet transfusion.

Group Type ACTIVE_COMPARATOR

Platelet transfusion

Intervention Type BIOLOGICAL

Platelets (10 ml/kg body weight) is transfused.

Fibrinogen

Patients recieve, in the presence of significant bleeding and pathological results of ROTEM analysis, fibrinogen concentrate.

Group Type EXPERIMENTAL

Fibrinogen concentrate

Intervention Type BIOLOGICAL

Fibrinogen concentrate (300 mg/kg body weight) is administered.

Interventions

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Platelet transfusion

Platelets (10 ml/kg body weight) is transfused.

Intervention Type BIOLOGICAL

Fibrinogen concentrate

Fibrinogen concentrate (300 mg/kg body weight) is administered.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Children \< 1 years of age, scheduled for open surgery of congenital heart defects, using cardiopulmonary bypass.
* Body weight \< 10 kg.
* Expected CPB time \> 90 minutes.

Exclusion Criteria

* Known coagulation disorder, current treatment with antiplatelet and/or anticoagulant drugs, major surgery the past month before the planned surgery, preoperative kidney or liver failure (defined as creatinine and/or transaminases \> normal interval for the patient´s age), gestational age \< 34 weeks.
Maximum Eligible Age

12 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Fredrik Söderlund

Consultant, Anaesthesia and Intensive Care

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Fredrik Söderlund, MD

Role: CONTACT

+46 31 343 6895

Birgitta Romlin, MD, PhD

Role: CONTACT

+46 31 343 5370

Facility Contacts

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Fredrik Söderlund, MD

Role: primary

+46733829802

Birgitta Romlin, MD, PhD

Role: backup

Other Identifiers

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FS52016

Identifier Type: -

Identifier Source: org_study_id

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