Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2008-01-01
2020-12-31
Brief Summary
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Detailed Description
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Study Protocol: examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation.
Research method: scanning electron microscopy (SEM) of the central retina (macular and paramacular zone): ILM, preretinal vitreous.
Scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous.
Expected results: determination of ILM thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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cadaver eyes
The Central region of the retina and preretinal structures of cadaver eyes are examined
scanning electron microscopy
scanning electron microscopy of the сentral retina and preretinal structures
Interventions
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scanning electron microscopy
scanning electron microscopy of the сentral retina and preretinal structures
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
35 Years
45 Years
ALL
No
Sponsors
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The S.N. Fyodorov Eye Microsurgery State Institution
OTHER_GOV
Responsible Party
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Lyskin Pavel Vladimirovich, MD, PhD
MD, PhD, ophthalmosurgeon
Principal Investigators
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Pavel V Lyskin, PhD
Role: PRINCIPAL_INVESTIGATOR
The S.N. Fyodorov Eye Microsurgery State Institution
Locations
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S.N. Fedorov Nmrc "Mntk "Eye Microsurgery"
Moscow, , Russia
Countries
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Related Links
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Microanatomy of vitreoretinal interactions in macular and paramacular areas (article DOI: 10.17816/KMJ2019-595)
Microanatomy of Internal Limiting Membrane (article)
Cellular Microanatomy of Vitreoretinal Interface. Morphofunctional Identification of Epiretinal Vitreous Cells. Collagen Synthesis in Adult Human Vitreous (article)
New Data of Mechanism in Vitreoretinal Adhesion and Posterior Vitreous Detachment in Humans (article)
Antithesis to the thesis about fibronectin and laminin as the main components providing vitreoretinal adhesion (article)
Other Identifiers
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124576
Identifier Type: -
Identifier Source: org_study_id
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