Tear Film SARS-nCoV-2 Detection in Symptomatic and Pauci-symptomatic Patients.

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-11

Study Completion Date

2020-12-13

Brief Summary

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To investigate the presence of SARS-nCoV-2 in the tear film of symptomatic and pauci-symptomatic SARS-nCoV-2 positive patients.

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Detailed Description

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The end goal of the study is to show whether or not the virus can be found in the tear film in both symptomatic and less symptomatic patients by means of serial sampling.

A sample of the tears / conjunctiva will be taken with a soft brush (similar to a cotton swab) every three days until the end of the hospitalization. In addition, you must complete a questionnaire that assesses the symptoms present.

Conditions

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Covid19 Eye Diseases

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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symptomatic patient

to confirm the detectability of the SARS-nCoV-2 in the tear film of symptomatic patients.

swabbing of conjunctiva

Intervention Type DIAGNOSTIC_TEST

Each eye will be sampled with a single, sterile, nylon, flocked swab

Interventions

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swabbing of conjunctiva

Each eye will be sampled with a single, sterile, nylon, flocked swab

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Subject needs to be above 18 years old.
* The subject is willing to undergo sampling of the conjunctiva.
* The subject is willing to fill in a questionnaire.
* The subject is fluent in written and verbal Dutch.
* The subject is capable of giving informed consent.
* Applicable for part 1 only: the subject test positive for SARS-nCoV-2 on a nasopharyngeal swab. The time window between a positive nasopharyngeal swab and the first conjunctival swab may be no more than 3 days.