Study of CC-96191 in Participants With Relapsed or Refractory Acute Myeloid Leukemia

NCT ID: NCT04789655

Last Updated: 2025-05-31

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 45 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-06-16
• Study Completion Date: 2025-04-14

Brief Summary

This Phase 1, clinical study of CC-96191 will explore the safety, tolerability and preliminary biological and clinical activity of CC-96191 as a single-agent in the setting of Relapsed or refractory acute myeloid leukemia (R/R AML).

The dose escalation (Part A) of the study will explore escalating intravenous doses of CC-96191 to estimate the MTD and/or RP2D of CC-96191 as monotherapy.

The expansion (Part B), will further evaluate the safety and efficacy of CC-96191 administered at or below the MTD in one or more expansion cohorts in order to determine the RP2D.

Conditions

Leukemia, Myeloid

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

CC-96191

CC-96191 will be administered intravenously on a 28-day Cycle

Group Type: EXPERIMENTAL

CC-96191

Intervention Type: DRUG

CC-96191

Interventions

CC-96191

CC-96191

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Participants must satisfy the following criteria to be enrolled in the study:.
• Participant must understand and voluntarily sign an informed consent form (ICF) prior to any study-related assessments/procedures being conducted.
• Participant is ≥ 18 years of age at the time of signing the ICF.
• Relapsed or refractory CD33 positive AML at last visit as defined by the World Health Organization (WHO) Classification who have failed or who are ineligible for or have refused all available therapies for AML which may provide clinical benefit.
• Participant has Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.
• At least 4 weeks (from first dose) has elapsed from donor lymphocyte infusion without conditioning.
• Females and males must practice true abstinence or agree to contraceptive methods throughout the study, and during the safety follow-up period.

Exclusion Criteria

• The presence of any of the following will exclude a Participant from enrollment:.
• Participant is suspected or proven to have acute promyelocytic leukemia (FAB M3) based on morphology, immunophenotype, molecular assay, or karyotype.
• Participant has received systemic anticancer therapy (including investigational therapy) or radiotherapy < 28 days or 5 half-lives, whichever is shorter, prior to the start of study treatment. Hydroxyurea is allowed to control peripheral leukemia blasts.
• Participants with prior autologous hematopoietic stem cell transplant who, in the investigator's judgment, have not fully recovered from the effects of the last transplant (eg, transplant-related side effects).
• Prior allogeneic HSCT with either standard or reduced intensity conditioning ≤ 6 months prior to dosing.
• Participants on systemic immunosuppressive therapy post HSCT at the time of screening, or with clinically significant graft-versus-host disease (GVHD). The use of topical steroids for ongoing skin or ocular GVHD is permitted.
• Participant has persistent, clinically significant non-hematologic toxicities from prior therapies which have not recovered to < Grade 2.
• Participant has or is suspected of having central nervous system (CNS) leukemia. Evaluation of cerebrospinal fluid is only required if CNS involvement by leukemia is suspected during screening.
• History of concurrent second cancers requiring active, ongoing systemic treatment.
• Participant is known seropositive or active infection with human immunodeficiency virus (HIV), or active infection with hepatitis B virus or hepatitis C virus.
• Impaired cardiac function or clinically significant cardiac diseases, as defined in the protocol.
• Participant is a pregnant or lactating female.
• Participant with isolated extramedullary disease without bone marrow involvement.
• Inadequate pulmonary function as defined as oxygen saturation (SpO2) < 92% on room air.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Celgene

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

Local Institution - 109

Birmingham, Alabama, United States

Local Institution - 105

Jacksonville, Florida, United States

Local Institution - 108

Atlanta, Georgia, United States

Local Institution - 110

Rochester, Minnesota, United States

Local Institution - 101

Hackensack, New Jersey, United States

Local Institution - 102

New York, New York, United States

Local Institution - 107

Houston, Texas, United States

Local Institution - 111

Seattle, Washington, United States

Local Institution - 202

Calgary, Alberta, Canada

Local Institution - 201

Toronto, Ontario, Canada

Local Institution - 303

Marseille, , France

Local Institution - 304

Paris, , France

Local Institution - 301

Pessac, , France

Local Institution - 302

Villejuif, , France

Countries

United States; Canada; France

References

Lunn-Halbert MC, Laszlo GS, Erraiss S, Orr MT, Jessup HK, Thomas HJ, Chan H, Jahromi MA, Lloyd J, Cheung AF, Chang GP, Dichwalkar T, Fallon D, Grinberg A, Rodriguez-Arboli E, Lim SYT, Kehret AR, Huo J, Cole FM, Scharffenberger SC, Walter RB. Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16a/NKG2D Immune-Modulating TriNKET(R) CC-96191. Cancers (Basel). 2024 Feb 22;16(5):877. doi: 10.3390/cancers16050877.

Reference Type: DERIVED

PMID: 38473239 (View on PubMed)

Related Links

https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

BMS Clinical Trial Information

https://www.BMSClinicalTrials.com

BMS Clinical Trial Patient Recruiting

Other Identifiers

U1111-1264-5412

Identifier Type: REGISTRY

Identifier Source: secondary_id

2022-500573-13-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

CC-96191-AML-001

Identifier Type: -

Identifier Source: org_study_id