COVID-19 Infection and Epithelial Cell Markers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

235 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-14

Study Completion Date

2022-02-01

Brief Summary

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To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.

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Detailed Description

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The study aim is to determine the relationship between COVID-19 infection and epithelial cell expression of TSLP. Two cohorts will be used. Cohort One will include 100 hospitalized patients with Covid-19, and 100 hospitalized patients without Covid-19. Cohort 2 will include mild/moderate asthmatics and healthy controls with bio-banked biopsy material used from donors who have previously consented for samples to be used for future research.

Conditions

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Asthma Covid19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Hospitalized patients

100 patients hospitalized with Covid-19, and 100 hospitalized controls without Covid-19

No interventions assigned to this group

Mild/Moderate asthma and health controls

20 asthmatic patients, 10 patients with asthma and allergic rhinitis, and 5 healthy controls.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 18 years and above;
* Able to give informed consent;
* Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g. RT-PCR) and with a positive result and clinical features in keeping with COVID-19 illness. The control group will be patients with a negative RT-PCR COVID-19 test and without any clinical features to suggest COVID-19 illness. In addition, the control group should have NO known or current features of respiratory infection, COPD, asthma, interstitial lung disease, other respiratory inflammatory conditions or lung cancer.
* Able to provide a breath sample (as based on clinical judgement).