Quantitative MRI of Bone Marrow Fat Fraction in Patients With Trepanobiopsy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-16

Study Completion Date

2024-01-01

Brief Summary

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The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.

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Detailed Description

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The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow.

MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.

Conditions

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Aplastic Anemia Aplastic Anemia Idiopathic

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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Bone marrow cellularity by mDixon-quant

if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

presence of indications for performing trepanobiopsy:

1. aplastic anemia
2. chronic myeloproliferative disease
3. reactive changes in hematopoiesis

Exclusion Criteria

1. Refusal to sign an informed consent to participate in a clinical trial
2. Presence of contraindications for MRI examination
3. Extremely serious condition of the patient at the time of inclusion in the study.

Minimum Eligible Age

6 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No