Immuno 1: Immune Reconstitution Following Conventional or High-Dose Chemotherapy With Stem Cell Transplant
NCT ID: NCT00231712
Last Updated: 2006-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2005-03-31
2009-02-28
Brief Summary
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1. conventional chemotherapy
2. high-dose chemotherapy followed by autologous stem cell transplant
3. high-dose chemotherapy followed by allogeneic stem cell transplant on the recovery of the immune system.
Detailed analysis will help to better understand the pathways of recovery of the immune system following chemotherapy as well as the pathways of recovery of the immune system following autologous or allogeneic stem cell transplantation.
Detailed Description
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* standard flow cytometry in combination with intracellular cytokine/antigen staining
* spectratype analysis
* TREC assays
Conditions
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Keywords
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Study Design
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DEFINED_POPULATION
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Solid tumor treated according to current GPOH-protocol
* Medulloblastoma treated according to HIT-2000 protocol
* High-dose chemotherapy followed by autologous stem cell transplantation
* High-dose chemotherapy followed by allogeneic stem cell transplantation
* Written consent according to our institutional guidelines
Exclusion Criteria
0 Years
ALL
No
Sponsors
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University of Wuerzburg
OTHER
Julius-Maximilians University
OTHER
Principal Investigators
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Paul G Schlegel, MD
Role: PRINCIPAL_INVESTIGATOR
University Children's Hospital Pediatric Oncology Wuerzburg / Germany
Matthias Eyrich, MD
Role: STUDY_DIRECTOR
Pediatric Stem Cell Transplant Program
Locations
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University Children's Hospital Pedaitric Oncology
Würzburg, , Germany
Countries
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Central Contacts
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Facility Contacts
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Beate Winkler, MD
Role: primary
References
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Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brugger D, Bader P, Lang P, Schilbach K, Winkler B, Niethammer D, Schlegel PG. Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. Biol Blood Marrow Transplant. 2005 Mar;11(3):194-205. doi: 10.1016/j.bbmt.2004.12.001.
Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG. A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors vs recipients of unmanipulated bone marrow from related donors. Bone Marrow Transplant. 2003 Aug;32(4):379-90. doi: 10.1038/sj.bmt.1704158.
Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, Niethammer D, Schlegel PG. Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors. Blood. 2002 Sep 1;100(5):1915-8. doi: 10.1182/blood-2001-11-0005.
Other Identifiers
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133/04
Identifier Type: -
Identifier Source: org_study_id