Segmentation of Structural Abnormalities in Chronic Lung Diseases

NCT ID: NCT04760548

Last Updated: 2024-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2024-02-17

Brief Summary

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Lung structural abnormalities are complex, time-consuming, and may lack reproducibility to evaluate visually on CT scans. The study's aim is to perform automated recognition of structural abnormalities in CT scans of patients with chronic lung diseases by using dedicated software.

Detailed Description

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Three chronic lung diseases will constitute the target of the study, by using retrospective data from each lung disease:

* Cystic fibrosis
* Asthma and COPD
* Interstitial lung diseases

Dedicated algorithms will be developped for each disease condition.

Conditions

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Cystic Fibrosis Asthma COPD Interstitial Lung Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Train dataset

This group is dedicated to developing an automated algorithm

Observational study

Intervention Type OTHER

Test dataset

This group is dedicated to testing the semantic performance of an automated algorithm

Observational study

Intervention Type OTHER

Clinical Validations

Patients groups are dedicated to assessing the clinical validity of the measurement in independent validation cohorts, with or without longitudinal evaluations such as monitoring of a treatment effect

Observational study

Intervention Type OTHER

Interventions

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Observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with chronic lung disease and clinical examination, pulmonary function test, and CT acquired during a routine follow-up
Minimum Eligible Age

3 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

Collaborative NOVAA study group

UNKNOWN

Sponsor Role collaborator

Hôpital Haut Lévêque

OTHER

Sponsor Role lead

Responsible Party

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Hôpital Haut Lévêque

Director

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Patrick Berger, Pr

Role: STUDY_CHAIR

Hopital Haut Leveque

Locations

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Hopital Haut Leveque

Pessac, , France

Site Status

Countries

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France

References

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Dournes G, Hall CS, Willmering MM, Brody AS, Macey J, Bui S, Denis de Senneville B, Berger P, Laurent F, Benlala I, Woods JC. Artificial intelligence in computed tomography for quantifying lung changes in the era of CFTR modulators. Eur Respir J. 2022 Mar 3;59(3):2100844. doi: 10.1183/13993003.00844-2021. Print 2022 Mar.

Reference Type DERIVED
PMID: 34266943 (View on PubMed)

Other Identifiers

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NOVAA

Identifier Type: -

Identifier Source: org_study_id

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