An Investigation of the Effects of Opioid Receptor Blockade on Changes in Self-esteem and Social Attention

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-09

Study Completion Date

2013-03-15

Brief Summary

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The purpose of this study is to explore the effects of endogenous opioids on self-esteem and attentional bias toward social cues. This is achieved by administering the drug naltrexone, which temporarily decreases endogenous opioid activity.

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Detailed Description

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Conditions

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Self Esteem

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

cellulose-filled capsule

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Naltrexone

single 50 mg oral dose naltrexone (capsule)

Group Type EXPERIMENTAL

Naltrexone

Intervention Type DRUG

opioid receptor antagonist

Interventions

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Naltrexone

opioid receptor antagonist

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* good physical health,
* normal kidney and liver function results from within previous year

Exclusion Criteria

* allergy to naltrexone
* kidney or liver injury or disorder
* bipolar, panic, or psychotic disorders
* epilepsy
* smoking more than 15 cigarettes per day
* pregnancy
* substance abuse
* use of opioid analgesics, cocaine, recreational drugs (e.g., marijuana, LSD, ecstasy, etc.), or prescription medication (except oral contraceptives) within the past 10 days
* use of over-the-counter drugs (e.g., analgesics, anti-inflammatories, sleeping aids, etc.) or alcohol within the past 24 hours
* current experience of pain (e.g., headache)
* use of anti-diarrheal medications in the 7 days prior to the study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes