Effect of Using Different Varnishes on Dentin Hypersensitivity; Na Fluoride and Nano-silver Fluoride

NCT ID: NCT04731766

Last Updated: 2021-02-01

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-11-01
• Study Completion Date: 2022-01-01

Brief Summary

2 different varnishes will be used to test their effectiveness in controlling teeth hypersensitivity in adult patient.

Detailed Description

In-vivo part:

Each varnish will be applied separately on different teeth according to the manufacturer's instructions and the VAS will be measured according to a specific timeline: T0 (baseline, before application of varnish), T1 (1 week after application), T2 (4 weeks after application) and T3 (4 weeks after application).

In-situ part:

Dentin specimen will be prepared from extracted teeth from the orthodontic department in our college, sterilized and prepared.

it will be bonded to an orthodontic wire and bonded to upper first molar. Dentinal occlusion will be measured using scanning electron microscope following the same timeline.

Conditions

Dentin Hypersensitivity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: TRIPLE

Study Groups

Citrine 5% Sodium Fluoride

It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

Group Type: ACTIVE_COMPARATOR

Citrine 5 % sodium fluoride

Intervention Type: BEHAVIORAL

Citrine varnish is a 5% sodium fluoride varnish, It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

concocuted Nano-silver fluoride

Nano-silver fluoride (NSF) is a laboratory synthesized solution

Group Type: EXPERIMENTAL

concocted nano-silver fluoride

Intervention Type: BEHAVIORAL

Nano-silver fluoride (NSF) is a solution which has been introduced as an experimental formulation in which it's stability for three years has been proved by Santos et al. The laboratory synthesis of concocted NSF was carried out in a nano-technology center; Several trials were done until we have reached a successful end product.

Interventions

Citrine 5 % sodium fluoride

Citrine varnish is a 5% sodium fluoride varnish, It was developed to prolong the contact between the tooth surface and fluoride to increase the resistance against caries attack and manage tooth hypersensitivity; the active ingredient of fluoride varnish is mostly 5% sodium fluoride.

Intervention Type: BEHAVIORAL

concocted nano-silver fluoride

Nano-silver fluoride (NSF) is a solution which has been introduced as an experimental formulation in which it's stability for three years has been proved by Santos et al. The laboratory synthesis of concocted NSF was carried out in a nano-technology center; Several trials were done until we have reached a successful end product.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Patients consulting in one of the Qasr Einy, faculty of dentistry outpatient clinics.
• Males or females.
• Patient's age range 25-50 years.
• Patients complaining of hypersensitive areas on facial surfaces of the teeth (incisors, cuspids, bi-cuspids, and first molars with exposed cervical dentine) with teeth scoring Bpain (VAS score: greater than or equal to 3) during application of stimulus (airblast and tactile sensitivity test).
• Tooth with exposed root surface, complaining from hypersensitivity (VAS score; greater than or equal to 3).
• Patients accept the 2-months follow-up period.
• Provide informed consent.

Exclusion Criteria

• • Patients participating in another dental study that may alter the results of this study.

• A medical condition that could hinder the accuracy of pain reporting (e.g., pain disorders).
• Any chronic medical condition that requires the regular use of anti-inflammatory pain medications.
• Patients used or applied a desensitizing varnish within the last four weeks.
• Patients with dental problems; chipped teeth, defective restorations, fractured Un-displaced cuspids or deep dental caries.
• Lack of patient's approval and compliance.

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Nayera Hassanien Mohamed

OTHER

Sponsor Role: lead

Responsible Party

Nayera Hassanien Mohamed

Assistant Lecturer

Responsibility Role: SPONSOR_INVESTIGATOR

Other Identifiers

205

Identifier Type: -

Identifier Source: org_study_id