Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score

NCT ID: NCT04730752

Last Updated: 2021-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

174 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2021-05-25

Brief Summary

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Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases. Despite the advances and widespread use of imaging modalities, still negative laparotomies are performed with the initial diagnosis of acute appendicitis. Several scoring systems are developed by using various clinical and laboratory parameters in order to improve the diagnostic accuracy and prevent unnecessary laparotomies.

Detailed Description

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In the recent guideline of World Society of Emergency Surgeons (WSES) recommendations regarding the clinical scoring systems for acute appendicitis are remarkable. It is stated that clinical scoring systems, on their own, can be used to exclude acute appendicitis and decrease negative laparotomy rates. Currently Appendicitis Inflammatory Response Score (AIR) and Adult Appendicitis Score (AAS) are the best clinically performing scoring systems. As a result, based on strong evidence the use of these two systems are recommended. Both scoring systems are developed on the basis of clinical findings and laboratory parameters.

The aim of this study is to validate both systems as well as to compare the efficiency of both systems on excluding negative laparotomies and on the determination of severity of acute appendicitis.

Conditions

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Acute Appendicitis Acute Appendicitis With Rupture

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Right Low Quadrant Pain

AIR and AAS scores will be calculated for the patients with right low quadrant pain in emergency service.

Appendicitis Inflammatory Response

Intervention Type DIAGNOSTIC_TEST

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Adult Appendicitis Score

Intervention Type DIAGNOSTIC_TEST

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Interventions

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Appendicitis Inflammatory Response

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Intervention Type DIAGNOSTIC_TEST

Adult Appendicitis Score

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Presenting to ER with right lower quadrant pain
* Patients between 18-65 years old.

Exclusion Criteria

* Patients receiving immun-suppressive therapy
* Patients with diagnosed malignancy
* Presence of mental retardation
* Patients with previous right hemicolectomy
* Patients with previous appendectomy
* Pregnant women
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nigde Omer Halisdemir University

OTHER

Sponsor Role lead

Responsible Party

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Alirıza Erdoğan

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Niğde Ömer Halisdemir University Training and Research Hospital

Niğde, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Ohle R, O'Reilly F, O'Brien KK, Fahey T, Dimitrov BD. The Alvarado score for predicting acute appendicitis: a systematic review. BMC Med. 2011 Dec 28;9:139. doi: 10.1186/1741-7015-9-139.

Reference Type BACKGROUND
PMID: 22204638 (View on PubMed)

Huckins DS, Copeland K. Diagnostic accuracy of combined WBC, ANC and CRP in adult emergency department patients suspected of acute appendicitis. Am J Emerg Med. 2021 Jun;44:401-406. doi: 10.1016/j.ajem.2020.04.086. Epub 2020 Apr 29.

Reference Type BACKGROUND
PMID: 32482481 (View on PubMed)

Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, Boermeester M, Sartelli M, Coccolini F, Tarasconi A, De' Angelis N, Weber DG, Tolonen M, Birindelli A, Biffl W, Moore EE, Kelly M, Soreide K, Kashuk J, Ten Broek R, Gomes CA, Sugrue M, Davies RJ, Damaskos D, Leppaniemi A, Kirkpatrick A, Peitzman AB, Fraga GP, Maier RV, Coimbra R, Chiarugi M, Sganga G, Pisanu A, De' Angelis GL, Tan E, Van Goor H, Pata F, Di Carlo I, Chiara O, Litvin A, Campanile FC, Sakakushev B, Tomadze G, Demetrashvili Z, Latifi R, Abu-Zidan F, Romeo O, Segovia-Lohse H, Baiocchi G, Costa D, Rizoli S, Balogh ZJ, Bendinelli C, Scalea T, Ivatury R, Velmahos G, Andersson R, Kluger Y, Ansaloni L, Catena F. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27. doi: 10.1186/s13017-020-00306-3.

Reference Type BACKGROUND
PMID: 32295644 (View on PubMed)

Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008 Aug;32(8):1843-9. doi: 10.1007/s00268-008-9649-y.

Reference Type BACKGROUND
PMID: 18553045 (View on PubMed)

Sammalkorpi HE, Mentula P, Leppaniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014 Jun 26;14:114. doi: 10.1186/1471-230X-14-114.

Reference Type BACKGROUND
PMID: 24970111 (View on PubMed)

Other Identifiers

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2021/07

Identifier Type: -

Identifier Source: org_study_id

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