Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
NCT ID: NCT04700124
Last Updated: 2026-02-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
808 participants
INTERVENTIONAL
2021-04-21
2025-10-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Arm A: Perioperative EV+ Pembrolizumab and RC + PLND
Participants receive 4 cycles (each cycle length = 21 days) of EV intravenous (IV) infusion plus pembrolizumab IV infusion preoperatively, followed by RC + PLND, followed by 5 cycles of adjuvant EV IV infusion plus 13 cycles of adjuvant pembrolizumab IV infusion postoperatively. The total treatment duration is up to approximately 1 year.
Pembrolizumab
200 mg of Pembrolizumab IV infusion, on Day 1 Q3W for 4 cycles (each cycle length = 21 days) in preoperative phase (up to approximately 3 months) and on Day 1 Q3W for 13 cycles in postoperative phase (up to approximately 9 months). The total duration of treatment is up to approximately 1 year.
Enfortumab vedotin (EV)
1.25 mg/kg of EV IV infusion, on Day 1 and Day 8 Q3W for 4 cycles (each cycle length = 21 days) in preoperative phase (up to approximately 3 months) and on Day 1 and Day 8 Q3W for 5 cycles (each cycle length = 21 days) in postoperative phase (up to approximately 4 months). The total duration of treatment is up to approximately 7 months.
RC + PLND
Curative intent RC + PLND surgery will be administered to all participants randomized to Arm A and B after completion of preoperative systemic treatment (RC + PLND to be done approximately at 15 weeks from randomization).
Arm B: Standard of Care (SOC)-Neoadjuvant chemotherapy (gemcitabine + cisplatin) and RC + PLND
Participants receive 4 cycles (each cycle length = 21 days) of standard of care (SOC) chemotherapy (gemcitabine IV infusion plus cisplatin IV infusion) preoperatively, followed by RC + PLND. The total treatment duration is up to approximately 3 months.
RC + PLND
Curative intent RC + PLND surgery will be administered to all participants randomized to Arm A and B after completion of preoperative systemic treatment (RC + PLND to be done approximately at 15 weeks from randomization).
Gemcitabine
1000 mg/m\^2 of Gemcitabine IV infusion, Day 1 and Day 8 Q3W for 4 cycles in preoperative phase (up to approximately 3 months)
Cisplatin
70 mg/m\^2 of Cisplatin IV infusion, Day 1, Q3W for 4 cycles in preoperative phase (up to approximately 3 months)
Interventions
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Pembrolizumab
200 mg of Pembrolizumab IV infusion, on Day 1 Q3W for 4 cycles (each cycle length = 21 days) in preoperative phase (up to approximately 3 months) and on Day 1 Q3W for 13 cycles in postoperative phase (up to approximately 9 months). The total duration of treatment is up to approximately 1 year.
Enfortumab vedotin (EV)
1.25 mg/kg of EV IV infusion, on Day 1 and Day 8 Q3W for 4 cycles (each cycle length = 21 days) in preoperative phase (up to approximately 3 months) and on Day 1 and Day 8 Q3W for 5 cycles (each cycle length = 21 days) in postoperative phase (up to approximately 4 months). The total duration of treatment is up to approximately 7 months.
RC + PLND
Curative intent RC + PLND surgery will be administered to all participants randomized to Arm A and B after completion of preoperative systemic treatment (RC + PLND to be done approximately at 15 weeks from randomization).
Gemcitabine
1000 mg/m\^2 of Gemcitabine IV infusion, Day 1 and Day 8 Q3W for 4 cycles in preoperative phase (up to approximately 3 months)
Cisplatin
70 mg/m\^2 of Cisplatin IV infusion, Day 1, Q3W for 4 cycles in preoperative phase (up to approximately 3 months)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Have clinically non-metastatic bladder cancer (N≤1 M0) determined by imaging (computed tomography (CT) or magnetic resonance imaging (MRI) of the chest/abdomen/pelvis
* Be deemed eligible for Radical Cystectomy (RC) + Pelvic Lymph Node Dissection (PLND)
* Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Have adequate organ function.
Exclusion Criteria
* Has received any prior systemic treatment for MIBC or non-invasive muscle bladder cancer (NMIBC - prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
* Has ≥N2 disease or metastatic disease (M1) as identified by imaging
* Is cisplatin-ineligible, as defined by meeting any one of the cisplatin ineligibility criteria as per protocol
* Has received prior systemic anticancer therapy including investigational agents within 3 years of randomization or any radiotherapy to the bladder
* Has undergone partial cystectomy of the bladder to remove any NMIBC or MIBC
* Has received a live or live attenuated vaccine within 30 days before the first dose of study intervention
* Has a diagnosis of immunodeficiency or has a known history of human immunodeficiency virus (HIV) infection. Hepatitis B infection or known active Hepatitis C infection
* Has a known psychiatric or substance abuse disorder
* Has had an allogenic tissue/solid organ transplant
* Has ongoing sensory or motor neuropathy Grade 2 or higher
* Has active keratitis (superficial punctate keratitis) or corneal ulcerations
* Has a history of uncontrolled diabetes defined as hemoglobin A1c (HbA1c) ≥8% or HbA1c 7% to \<8% with associated diabetes symptoms
18 Years
ALL
No
Sponsors
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Seagen Inc.
INDUSTRY
Astellas Pharma Inc
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY
Responsible Party
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Principal Investigators
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Medical Director
Role: STUDY_DIRECTOR
Merck Sharp & Dohme LLC
Locations
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Mayo Clinic in Arizona - Phoenix ( Site 0043)
Phoenix, Arizona, United States
St Joseph Heritage Healthcare-Oncology ( Site 0035)
Fullerton, California, United States
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 0005)
Los Angeles, California, United States
University of California San Francisco ( Site 0010)
San Francisco, California, United States
Stanford University ( Site 0023)
Stanford, California, United States
University of Colorado, Anschutz Cancer Pavilion ( Site 0009)
Aurora, Colorado, United States
UF Health ( Site 0031)
Gainesville, Florida, United States
Indiana University Melvin and Bren Simon Cancer Center ( Site 0050)
Indianapolis, Indiana, United States
University of Iowa Hospital and Clinics ( Site 0029)
Iowa City, Iowa, United States
University of Louisville, James Graham Brown Cancer Center ( Site 0022)
Louisville, Kentucky, United States
Icahn School of Medicine at Mount Sinai ( Site 0011)
New York, New York, United States
White Plains Hospital ( Site 0039)
White Plains, New York, United States
Duke University Medical Center ( Site 0017)
Durham, North Carolina, United States
Wake Forest Baptist Health ( Site 0014)
Winston-Salem, North Carolina, United States
Oregon Health and Science University ( Site 0028)
Portland, Oregon, United States
MidLantic Urology ( Site 0002)
Bala-Cynwyd, Pennsylvania, United States
Saint Francis Cancer Center ( Site 0008)
Greenville, South Carolina, United States
The University of Tennessee Medical Center ( Site 0034)
Knoxville, Tennessee, United States
UT Southwestern Medical Center ( Site 0003)
Dallas, Texas, United States
Houston Methodist Urology Associates ( Site 0033)
Houston, Texas, United States
Urology of San Antonio ( Site 0020)
San Antonio, Texas, United States
University of Wisconsin Hospital and Clinics ( Site 0037)
Madison, Wisconsin, United States
Hospital Británico de Buenos Aires-Oncology ( Site 1551)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires ( Site 1554)
ABB, Buenos Aires F.D., Argentina
Asociación de Beneficencia Hospital Sirio Libanés ( Site 1553)
Buenos Aires, Buenos Aires F.D., Argentina
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 1558)
Buenos Aires, Buenos Aires F.D., Argentina
Fundacion Estudios Clinicos-Oncology ( Site 1557)
Rosario, Santa Fe Province, Argentina
Centro de Urología (CDU) ( Site 1552)
Buenos Aires, , Argentina
Macquarie University-MQ Health Clinical Trials Unit ( Site 1259)
Macquarie University, New South Wales, Australia
Mater Hospital Brisbane ( Site 1257)
South Brisbane, Queensland, Australia
Lyell McEwin Hospital ( Site 1252)
Elizabeth Vale, South Australia, Australia
Frankston Hospital-Oncology and Haematology ( Site 1258)
Frankston, Victoria, Australia
MHAT "Uni Hospital" OOD ( Site 1154)
Panagyurishte, Pazardzhik, Bulgaria
Complex Oncology Center Plovdiv ( Site 1151)
Plovdiv, , Bulgaria
MHAT Central Onco Hospital OOD ( Site 1158)
Plovdiv, , Bulgaria
MHAT Serdika ( Site 1152)
Sofia, , Bulgaria
BC Cancer - Vancouver Center ( Site 0110)
Vancouver, British Columbia, Canada
CancerCare Manitoba ( Site 0108)
Winnipeg, Manitoba, Canada
Moncton Hospital ( Site 0107)
Moncton, New Brunswick, Canada
Ottawa Hospital Research Institute ( Site 0109)
Ottawa, Ontario, Canada
Jewish General Hospital ( Site 0106)
Montreal, Quebec, Canada
SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 1406)
Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 1413)
Guangzhou, Guangdong, China
Hunan Cancer Hospital ( Site 1403)
Changsha, Hunan, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 1404)
Nanjing, Jiangsu, China
Nantong Tumor Hospital-Urology ( Site 1405)
Nantong, Jiangsu, China
Fudan University Shanghai Cancer Center-Urology department ( Site 1401)
Shanghai, Shanghai Municipality, China
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 1402)
Shanghai, Shanghai Municipality, China
Fundacion Colombiana de Cancerología Clinica Vida ( Site 1653)
Medellín, Antioquia, Colombia
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 1654)
Bogotá, Bogota D.C., Colombia
IMAT S.A.S ( Site 1652)
Montería, Departamento de Córdoba, Colombia
Fundación Cardiovascular de Colombia-Santander ( Site 1657)
Piedecuesta, Santander Department, Colombia
Fundación Valle del Lili ( Site 1656)
Cali, Valle del Cauca Department, Colombia
Klinički bolnički centar Sestre milosrdnice ( Site 1703)
Zagreb, City of Zagreb, Croatia
Klinički bolnički centar Zagreb-Klinika za onkologiju ( Site 1701)
Zagreb, City of Zagreb, Croatia
Klinički bolnički centar Osijek ( Site 1705)
Osijek, County of Osijek-Baranja, Croatia
Klinički Bolnički Centar Split-Oncology and Radiotherapy ( Site 1702)
Split, Split-Dalmatia County, Croatia
Fakultni nemocnice u sv. Anny v Brne ( Site 0253)
Brno, South Moravian, Czechia
Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 0254)
Hradec Králové, , Czechia
Fakultni Nemocnice Olomouc ( Site 0251)
Olomouc, , Czechia
Fakultni Thomayerova nemocnice ( Site 0252)
Prague, , Czechia
CHU La Timone ( Site 0456)
Marseille, Bouches-du-Rhone, France
CHU Jean Minjoz ( Site 0453)
Besançon, Doubs, France
C.H. regional Unv. de Brest - Hopital La Cavale Blanche - Institut de Cancerologie et d Imagerie ( Site 0461)
Brest, Finistere, France
Institut Universitaire du Cancer Toulouse - Oncopole ( Site 0455)
Toulouse, Haute-Garonne, France
CHU Limoges Hopital Dupuytren ( Site 0459)
Limoges, Haute-Vienne, France
CHU GRENOBLE ALPES ( Site 0468)
La Tronche, Isere, France
Centre Hospitalier Regional du Orleans ( Site 0463)
Orléans, Loiret, France
Polyclinique du Bois ( Site 0458)
Lille, Nord, France
Hopital Diaconesses Croix Saint Simon ( Site 0465)
Paris, , France
Gustave Roussy ( Site 0467)
Villejuif, Île-de-France Region, France
Universitaetsklinikum Freiburg ( Site 0512)
Freiburg im Breisgau, Baden-Wurttemberg, Germany
Universitaetsklinik fuer Urologie ( Site 0501)
Tübingen, Baden-Wurttemberg, Germany
Caritas Krankenhaus St. Josef ( Site 0502)
Regensburg, Bavaria, Germany
Universitaetsklinikum Wuerzburg ( Site 0520)
Würzburg, Bavaria, Germany
Kath. Krankenhaus Marienhospital. Universitaetsklinik ( Site 0511)
Herne, North Rhine-Westphalia, Germany
Universitaetsklinikum Muenster ( Site 0516)
Münster, North Rhine-Westphalia, Germany
Universitaetsklinikum Carl Gustav Carus ( Site 0509)
Dresden, Saxony, Germany
Krankenhaus Martha Maria Halle-Doelau ( Site 0507)
Halle, Saxony-Anhalt, Germany
Vivantes Klinikum Am Urban ( Site 0519)
Berlin, , Germany
UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0305)
Pátrai, Achaia, Greece
General Hospital of Athens "Alexandra" ( Site 0303)
Athens, Attica, Greece
Athens Medical Center ( Site 0304)
Athens, Attica, Greece
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 0301)
Chaïdári, Attica, Greece
University General Hospital of Larissa ( Site 0302)
Larissa, Thessaly, Greece
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 1010)
Szeged, Csongrád megye, Hungary
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1002)
Szolnok, Jász-Nagykun-Szolnok, Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, , Hungary
Rambam Health Care Campus-Oncology ( Site 0751)
Haifa, , Israel
Hadassah Medical Center-Oncology ( Site 0757)
Jerusalem, , Israel
Meir Medical Center-oncology ( Site 0754)
Kfar Saba, , Israel
Rabin Medical Center-Oncology ( Site 0752)
Petah Tikva, , Israel
Sheba Medical Center-ONCOLOGY ( Site 0753)
Ramat Gan, , Israel
Sourasky Medical Center-Oncology ( Site 0755)
Tel Aviv, , Israel
Yitzhak Shamir Medical Center-Oncology ( Site 0756)
Ẕerifin, , Israel
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0588)
Milan, Lombardy, Italy
Presidio Ospedaliero Santa Maria delle Grazie ( Site 0599)
Pozzuoli, Napoli, Italy
AOU San Luigi Gonzaga di Orbassano ( Site 0595)
Orbassano, Torino, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 0598)
Verona, Veneto, Italy
Azienda Ospedaliero Universitaria delle Marche-Clinica Oncologica ( Site 0593)
Ancona, , Italy
Ospedale Cannizzaro ( Site 0590)
Catania, , Italy
IRCCS Ospedale San Raffaele ( Site 0596)
Milan, , Italy
Istituto Oncologico Veneto IRCCS-Oncologia Medica 1 ( Site 0600)
Padua, , Italy
Nagoya University Hospital ( Site 1512)
Nagoya, Aichi-ken, Japan
Hirosaki University Hospital ( Site 1501)
Hirosaki, Aomori, Japan
University of Tsukuba Hospital ( Site 1502)
Tsukuba, Ibaraki, Japan
Kanazawa University Hospital ( Site 1509)
Kanazawa, Ishikawa-ken, Japan
Kitasato University Hospital ( Site 1506)
Sagamihara, Kanagawa, Japan
Yokohama City University Medical Center ( Site 1508)
Yokohama, Kanagawa, Japan
Kanagawa Cancer Center ( Site 1507)
Yokohama, Kanagawa, Japan
Tohoku University Hospital ( Site 1503)
Sendai, Miyagi, Japan
Hamamatsu University Hospital ( Site 1511)
Hamamatsu, Shizuoka, Japan
Gifu University Hospital ( Site 1513)
Gifu, , Japan
Nagasaki University Hospital ( Site 1517)
Nagasaki, , Japan
Okayama University Hospital ( Site 1516)
Okayama, , Japan
Osaka International Cancer Institute ( Site 1514)
Osaka, , Japan
Osaka Metropolitan University Hospital ( Site 1515)
Osaka, , Japan
Institute of Science Tokyo Hospital ( Site 1505)
Tokyo, , Japan
Keio University Hospital ( Site 1504)
Tokyo, , Japan
Toyama University Hospital ( Site 1510)
Toyama, , Japan
University Malaya Medical Centre ( Site 0352)
Lembah Pantai, Kuala Lumpur, Malaysia
Hospital Pulau Pinang ( Site 0355)
George Town, Pulau Pinang, Malaysia
Sarawak General Hospital ( Site 0351)
Kuching, Sarawak, Malaysia
Sunway Medical Centre ( Site 0353)
Petaling Jaya, Selangor, Malaysia
THE MEDICAL CITY ILOILO-The Medical City Iloilo - Clinical and Translational Research Institute-Ilo ( Site 0801)
Iloilo City, Iloilo, Philippines
Clinical Research Center Medic-R ( Site 1061)
Poznan, Greater Poland Voivodeship, Poland
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1057)
Siedlce, Masovian Voivodeship, Poland
Narodowy Instytut Onkologii ( Site 1051)
Warsaw, Masovian Voivodeship, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1053)
Przemyśl, Podkarpackie Voivodeship, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 1058)
Wrocław, Silesian Voivodeship, Poland
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 1055)
Koszalin, West Pomeranian Voivodeship, Poland
Unidade Local de Saude de Coimbra - Hospitais da Universidade de Coimbra ( Site 0406)
Coimbra, , Portugal
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0409)
Lisbon, , Portugal
Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 0401)
Lisbon, , Portugal
Unidade Local de Saude de Santo António - Hospital Santo António ( Site 0408)
Porto, , Portugal
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L. ( Site 1104)
Bucharest, București, Romania
Cardiomed SRL Cluj-Napoca ( Site 1101)
Cluj-Napoca, Cluj, Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1102)
Cluj-Napoca, Cluj, Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1103)
Cluj-Napoca, Cluj, Romania
SC Radiotherapy Center Cluj SRL ( Site 1108)
Comuna Floresti, Cluj, Romania
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1107)
Craiova, Dolj, Romania
Policlinica Oncomed SRL ( Site 1106)
Timișoara, Timiș County, Romania
Institutul Oncologic Cluj-Oncologie Medicala ( Site 1109)
Cluj-Napoca, , Romania
Altay Regional Oncology Dispensary ( Site 0851)
Barnaul, Altayskiy Kray, Russia
National Medical Research Radiology Centre ( Site 0869)
Obninsk, Kaluzskaja Oblast, Russia
National Medical Research Centre of Oncology named after N.N. Blokhin ( Site 0865)
Moscow, Moscow, Russia
First Moscow State Medical University n.a. I.M.Sechenov ( Site 0871)
Moscow, Moscow, Russia
Volga District Medical Center ( Site 0876)
Nizhny Novgorod, Nizhny Novgorod Oblast, Russia
St.Petersburg Clinical Hospital RAS ( Site 0864)
Saint Petersburg, Sankt-Peterburg, Russia
St.Petersburg State Medical Univ. n.a. acad. I.P.Pavlov ( Site 0856)
Saint Petersburg, Sankt-Peterburg, Russia
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0852)
Saint Petersburg, Sankt-Peterburg, Russia
Sverdlovsk Regional Oncology Hospital ( Site 0867)
Yekaterinburg, Sverdlovsk Oblast, Russia
Sverdlovsky Regional Clinical hospital #1 ( Site 0868)
Yekaterinburg, Sverdlovsk Oblast, Russia
Volgograd Regional Uronephrological Center ( Site 0870)
Volzhsky, Volgograd Oblast, Russia
Tan Tock Seng Hospital ( Site 0704)
Singapore, Central Singapore, Singapore
Wits Clinical Research ( Site 0603)
Johannesburg, Gauteng, South Africa
Steve Biko Academic Hospital ( Site 0601)
Pretoria, Gauteng, South Africa
Groote Schuur Hospital ( Site 0602)
Cape Town, Western Cape, South Africa
Chonnam National University Hwasun Hospital ( Site 1353)
Jeollanam-do, Jeonranamdo, South Korea
Seoul National University Bundang Hospital ( Site 1355)
Gyeonggi-do, Kyonggi-do, South Korea
Kyungpook National University Chilgok Hospital ( Site 1354)
Daegu, Kyongsangbuk-do, South Korea
Asan Medical Center ( Site 1352)
Songpagu, Seoul, South Korea
Gachon University Gil Medical Center ( Site 1356)
Incheon, , South Korea
Korea University Anam Hospital ( Site 1357)
Seoul, , South Korea
Seoul National University Hospital ( Site 1351)
Seoul, , South Korea
Hospital Germans Trias i Pujol. ICO de Badalona ( Site 0658)
Badalona, Barcelona, Spain
Xarxa Assistencial Universitaria Manresa ( Site 0655)
Manresa, Barcelona, Spain
Institut Català d'Oncologia (ICO) - Girona ( Site 0653)
Girona, Gerona, Spain
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0660)
Santiago de Compostela, La Coruna, Spain
Hospital Universitario Insular de Gran Canaria ( Site 0657)
Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Universitario Central de Asturias ( Site 0654)
Oviedo, Principality of Asturias, Spain
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 0662)
Valencia, Valenciana, Comunitat, Spain
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0661)
Barcelona, , Spain
Hospital Clinico Universitario San Carlos de Madrid ( Site 0651)
Madrid, , Spain
Hospital Virgen del Rocio ( Site 0659)
Seville, , Spain
Chang Gung Memorial Hospital at Kaohsiung ( Site 1203)
Kaohsiung City, , Taiwan
China Medical University Hospital ( Site 1202)
Taichung, , Taiwan
Taipei Veterans General Hospital ( Site 1201)
Taipei, , Taiwan
I.I. Mechnykov Dnipropetrovsk Regional Clinical Hospital ( Site 0959)
Dnipro, Dnipropetrovsk Oblast, Ukraine
MI Clinical oncology dispensary of Dnipropetrovsk regional council ( Site 0954)
Dnipro, Dnipropetrovsk Oblast, Ukraine
Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval ( Site 0952)
Kharkiv, Kharkivs’ka Oblast’, Ukraine
MNPE Regional Center of Oncology ( Site 0955)
Kharkiv, Kharkivs’ka Oblast’, Ukraine
Municipal Non-profit Enterprise of Kharkiv Regional Council RCSDRPP ( Site 0965)
Kharkiv, Kharkivs’ka Oblast’, Ukraine
Lviv Oncology Regional Treatment and Diagnostic Center ( Site 0960)
Lviv, Lviv Oblast, Ukraine
Zhytomyr Regional Oncology Center ( Site 0961)
Zhytomyr, Zhytomyr Oblast, Ukraine
Torbay Hospital ( Site 1804)
Torquay, Devon, United Kingdom
Charing Cross Hospital-Oncology Research ( Site 1802)
London, Hammersmith and Fulham, United Kingdom
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 1801)
London, London, City of, United Kingdom
Countries
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Related Links
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Merck Clinical Trials Information
Plain Language Summary
Other Identifiers
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MK-3475-B15
Identifier Type: OTHER
Identifier Source: secondary_id
KEYNOTE-B15
Identifier Type: OTHER
Identifier Source: secondary_id
EV-304
Identifier Type: OTHER
Identifier Source: secondary_id
jRCT2041210011
Identifier Type: REGISTRY
Identifier Source: secondary_id
PHRR221021-005086
Identifier Type: REGISTRY
Identifier Source: secondary_id
2023-505615-21-00
Identifier Type: REGISTRY
Identifier Source: secondary_id
U1111-1292-1300
Identifier Type: REGISTRY
Identifier Source: secondary_id
2020-003106-31
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
3475-B15
Identifier Type: -
Identifier Source: org_study_id
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