Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

NCT ID: NCT03924856

Last Updated: 2025-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

907 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-06-13

Study Completion Date

2026-09-01

Brief Summary

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A global study to evaluate peri-operative pembrolizumab with chemotherapy versus placebo to pembrolizumab plus chemotherapy in cisplatin eligible patients.

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Detailed Description

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Conditions

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Bladder Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Double-blind

Study Groups

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Pembrolizumab + Gemcitabine + Cisplatin + Surgery

Participants received 4 preoperative cycles of pembrolizumab PLUS gemcitabine PLUS cisplatin, followed by surgery, followed by up to 13 cycles of postoperative pembrolizumab.

Group Type EXPERIMENTAL

Pembrolizumab

Intervention Type DRUG

Pembrolizumab 200 mg by intravenous (IV) infusion, given on Day 1 of each 21-day cycle

Gemcitabine

Intervention Type DRUG

Gemcitabine 1000 mg/m\^2, IV infusion on Days 1 and 8 of each 21-day cycle

Cisplatin

Intervention Type DRUG

Cisplatin 70 mg/m\^2, IV infusion on Day 1 of each 21-day cycle

Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND])

Intervention Type PROCEDURE

Surgical RC+PLND will be done in accordance with the American Urological Association (AUA)/American Society of Clinical Oncology (ASCO)/American Society for Radiation Oncology (ASTRO)/Society of Urologic Oncology (SUO) guidelines.

Placebo + Gemcitabine + Cisplatin + Surgery

Participants received 4 preoperative cycles of placebo to pembrolizumab PLUS gemcitabine PLUS cisplatin, followed by surgery, followed by up to 13 cycles of postoperative placebo to pembrolizumab.

Group Type PLACEBO_COMPARATOR

Gemcitabine

Intervention Type DRUG

Gemcitabine 1000 mg/m\^2, IV infusion on Days 1 and 8 of each 21-day cycle

Cisplatin

Intervention Type DRUG

Cisplatin 70 mg/m\^2, IV infusion on Day 1 of each 21-day cycle

Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND])

Intervention Type PROCEDURE

Surgical RC+PLND will be done in accordance with the American Urological Association (AUA)/American Society of Clinical Oncology (ASCO)/American Society for Radiation Oncology (ASTRO)/Society of Urologic Oncology (SUO) guidelines.

Placebo

Intervention Type DRUG

Placebo to pembrolizumab by IV infusion, given on Day 1 of each 21-day cycle

Interventions

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Pembrolizumab

Pembrolizumab 200 mg by intravenous (IV) infusion, given on Day 1 of each 21-day cycle

Intervention Type DRUG

Gemcitabine

Gemcitabine 1000 mg/m\^2, IV infusion on Days 1 and 8 of each 21-day cycle

Intervention Type DRUG

Cisplatin

Cisplatin 70 mg/m\^2, IV infusion on Day 1 of each 21-day cycle

Intervention Type DRUG

Surgery (radical cystectomy (RC) plus Pelvic Lymph Node Dissection [PLND])

Surgical RC+PLND will be done in accordance with the American Urological Association (AUA)/American Society of Clinical Oncology (ASCO)/American Society for Radiation Oncology (ASTRO)/Society of Urologic Oncology (SUO) guidelines.

Intervention Type PROCEDURE

Placebo

Placebo to pembrolizumab by IV infusion, given on Day 1 of each 21-day cycle

Intervention Type DRUG

Other Intervention Names

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MK-3475

Eligibility Criteria

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Inclusion Criteria

* Have a histologically confirmed diagnosis of urothelial carcinoma (UC) / muscle invasive bladder cancer (MIBC) (T2-T4aN0M0 or T1-T4aN1M0) with predominant (≥50%) urothelial histology.
* Have clinically non-metastatic bladder cancer (N≤1 M0) determined by imaging (computed tomography (CT) or magnetic resonance imaging (MRI)) of the chest/abdomen/pelvis.
* Be deemed eligible for Radical Cystectomy (RC) + Pelvic Lymph Node Dissection (PLND).
* Have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
* Have adequate organ function.
* Male and female participants are eligible to participate if they agree to the contraception use as per study protocol.

Exclusion Criteria

* Has a known additional malignancy that is progressing or has required active anti-cancer treatment ≤3 years of study randomization with certain exceptions.
* Has received any prior systemic treatment for MIBC or non-invasive muscle bladder cancer (NMIBC - prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).
* Has ≥N2 disease or metastatic disease (M1) as identified by imaging.
* Is cisplatin-ineligible, as defined by meeting any one of the cisplatin ineligibility criteria as per protocol.
* Has received prior systemic anticancer therapy including investigational agents within 3 years of randomization or any radiotherapy to the bladder.
* Has undergone partial cystectomy of the bladder to remove any NMIBC or MIBC.
* Has received a live or live attenuated vaccine within 30 days before the first dose of study intervention.
* Has a diagnosis of immunodeficiency or has a known history of human immunodeficiency virus (HIV) infection, Hepatitis B infection or known active Hepatitis C infection.
* Has a known psychiatric or substance abuse disorder.
* Has had an allogenic tissue/solid organ transplant.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

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Scripps MD Anderson ( Site 0010)

La Jolla, California, United States

Site Status

Providence Saint John's Health Center ( Site 0075)

Santa Monica, California, United States

Site Status

Georgetown University Medical Center ( Site 0022)

Washington D.C., District of Columbia, United States

Site Status

AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 0005)

Orlando, Florida, United States

Site Status

Parkview Cancer Institute ( Site 0077)

Fort Wayne, Indiana, United States

Site Status

Indiana University Melvin and Bren Simon Cancer Center ( Site 0004)

Indianapolis, Indiana, United States

Site Status

Ochsner Medical Center ( Site 0049)

New Orleans, Louisiana, United States

Site Status

New England Cancer Specialists ( Site 0070)

Scarborough, Maine, United States

Site Status

UMass Memorial Medical Center ( Site 0051)

Worcester, Massachusetts, United States

Site Status

Henry Ford Hospital ( Site 0039)

Detroit, Michigan, United States

Site Status

Mercy Hospital Saint Louis ( Site 0064)

St Louis, Missouri, United States

Site Status

Morristown Medical Center ( Site 0015)

Morristown, New Jersey, United States

Site Status

UNM Comprehensive Cancer Center-Clinical Research Office ( Site 0045)

Albuquerque, New Mexico, United States

Site Status

New York University Perlmutter Cancer Center ( Site 0008)

New York, New York, United States

Site Status

University Hospitals Cleveland Medical Center ( Site 0038)

Cleveland, Ohio, United States

Site Status

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021)

Tulsa, Oklahoma, United States

Site Status

Portland VA Medical Center ( Site 0084)

Portland, Oregon, United States

Site Status

Allegheny General Hospital ( Site 0048)

Pittsburgh, Pennsylvania, United States

Site Status

MD Anderson Cancer Center ( Site 0063)

Houston, Texas, United States

Site Status

Central Texas Veterans Healthcare System ( Site 0057)

Temple, Texas, United States

Site Status

Inova Schar Cancer Institute ( Site 0007)

Fairfax, Virginia, United States

Site Status

Northwest Medical Specialties, PLLC ( Site 0061)

Puyallup, Washington, United States

Site Status

Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0033)

Seattle, Washington, United States

Site Status

Charleston Area Medical Center ( Site 0023)

Charles Town, West Virginia, United States

Site Status

Mid North Coast Cancer Institute ( Site 1256)

Port Macquarie, New South Wales, Australia

Site Status

Southside Cancer Care Centre ( Site 1252)

Sydney, New South Wales, Australia

Site Status

Cairns Base Hospital ( Site 1257)

Cairns, Queensland, Australia

Site Status

Eastern Health ( Site 1255)

Box Hill, Victoria, Australia

Site Status

Peninsula Health Frankston Hospital ( Site 1258)

Frankston, Victoria, Australia

Site Status

UZ Brussel ( Site 0358)

Brussels, Bruxelles-Capitale, Region de, Belgium

Site Status

Jessa Ziekenhuis ( Site 0360)

Hasselt, Limburg, Belgium

Site Status

CHU UCL Namur Site de Godinne ( Site 0354)

Yvoir, Namur, Belgium

Site Status

O.L.V. Ziekenhuis Aalst ( Site 0356)

Aalst, Oost-Vlaanderen, Belgium

Site Status

AZ Maria Middelares Gent ( Site 0353)

Ghent, Oost-Vlaanderen, Belgium

Site Status

Tom Baker Cancer Centre ( Site 0100)

Calgary, Alberta, Canada

Site Status

Nova Scotia Health Authority ( Site 0109)

Halifax, Nova Scotia, Canada

Site Status

Kingston Health Sciences Centre ( Site 0103)

Kingston, Ontario, Canada

Site Status

Lakeridge Health ( Site 0104)

Oshawa, Ontario, Canada

Site Status

Sunnybrook Research Institute ( Site 0110)

Toronto, Ontario, Canada

Site Status

Princess Margaret Cancer Centre ( Site 0107)

Toronto, Ontario, Canada

Site Status

CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105)

Montreal, Quebec, Canada

Site Status

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0

Québec, Quebec, Canada

Site Status

Rigshospitalet University Hospital ( Site 0401)

Copenhagen, Capital Region, Denmark

Site Status

Herlev og Gentofte Hospital. ( Site 0402)

Herlev, Capital Region, Denmark

Site Status

Odense Universitetshospital ( Site 0403)

Odense, Region Syddanmark, Denmark

Site Status

CHU de Bordeaux- Hopital Saint Andre ( Site 0456)

Bordeaux, Aquitaine, France

Site Status

Centre Leon Berard ( Site 0465)

Lyon, Auvergne, France

Site Status

Centre Francois Baclesse ( Site 0459)

Caen, Calvados, France

Site Status

Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 0457)

Plérin, Cotes-d Armor, France

Site Status

Hopital Foch ( Site 0483)

Suresnes, Hauts-de-Seine, France

Site Status

CHU de Montpellier - Hopital Saint-Eloi ( Site 0469)

Montpellier, Languedoc-Roussillon, France

Site Status

Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0453)

Angers, Maine-et-Loire, France

Site Status

Hopital Robert Schuman ( Site 0452)

Metz, Moselle, France

Site Status

Centre Jean Perrin ( Site 0460)

Clermont-Ferrand, Puy-de-Dome, France

Site Status

Clinique Victor Hugo ( Site 0463)

Le Mans, Sarthe, France

Site Status

CHU de Rouen ( Site 0493)

Rouen, Seine-Maritime, France

Site Status

Institut Sainte Catherine ( Site 0454)

Avignon, Vaucluse, France

Site Status

Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0502)

Tübingen, Baden-Wurttemberg, Germany

Site Status

Universitaetsklinikum Erlangen ( Site 0505)

Erlangen, Bavaria, Germany

Site Status

Universitaetsklinikum Carl Gustav Carus ( Site 0519)

Dresden, Saxony, Germany

Site Status

Universitaetsklinikum Magdeburg A.o.R. ( Site 0516)

Magdeburg, Saxony-Anhalt, Germany

Site Status

Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0512)

Lübeck, Schleswig-Holstein, Germany

Site Status

Charite Universitaetsmedizin Berlin ( Site 0515)

Berlin, , Germany

Site Status

Vivantes Klinikum am Urban ( Site 0522)

Berlin, , Germany

Site Status

Pecsi Tudomanyegyetem AOK ( Site 1009)

Pécs, Baranya, Hungary

Site Status

SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010)

Szeged, Csongrád megye, Hungary

Site Status

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1002)

Szolnok, Jász-Nagykun-Szolnok, Hungary

Site Status

Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001)

Budapest, , Hungary

Site Status

Debreceni Egyetem Klinikai Kozpont ( Site 1006)

Debrecen, , Hungary

Site Status

Petz Aladar Megyei Oktato Korhaz ( Site 1012)

Győr, , Hungary

Site Status

Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1007)

Kaposvár, , Hungary

Site Status

Cork University Hospital ( Site 0722)

Cork, , Ireland

Site Status

Tallaght University Hospital ( Site 0710)

Dublin, , Ireland

Site Status

University Hospital Waterford ( Site 0723)

Waterford, , Ireland

Site Status

Ha Emek Medical Center ( Site 0808)

Afula, , Israel

Site Status

Soroka Medical Center ( Site 0806)

Beersheba, , Israel

Site Status

Rambam Health Care Campus-Oncology Division ( Site 0802)

Haifa, , Israel

Site Status

Shaare Zedek Medical Center ( Site 0809)

Jerusalem, , Israel

Site Status

Hadassah Ein Kerem Medical Center ( Site 0810)

Jerusalem, , Israel

Site Status

Meir Medical Center ( Site 0803)

Kfar Saba, , Israel

Site Status

Rabin Medical Center ( Site 0804)

Petah Tikva, , Israel

Site Status

Sheba Medical Center ( Site 0801)

Ramat Gan, , Israel

Site Status

Sourasky Medical Center ( Site 0807)

Tel Aviv, , Israel

Site Status

Yitzhak Shamir Medical Center ( Site 0805)

Ẕerifin, , Israel

Site Status

Policlinico Gemelli di Roma ( Site 0558)

Roma, Abruzzo, Italy

Site Status

Policlinico di Modena ( Site 0553)

Modena, Emilia-Romagna, Italy

Site Status

A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559)

Catania, , Italy

Site Status

Istituto Nazionale Studio e Cura dei Tumori ( Site 0551)

Milan, , Italy

Site Status

Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552)

Napoli, , Italy

Site Status

Fondazione Salvatore Maugeri IRCCS. ( Site 0554)

Pavia, , Italy

Site Status

Azienda Ospedaliera San Camillo Forlanini ( Site 0560)

Roma, , Italy

Site Status

Azienda Ospedaliera Santa Maria Terni ( Site 0557)

Terni, , Italy

Site Status

Hirosaki University Hospital ( Site 1502)

Hirosaki, Aomori, Japan

Site Status

National Cancer Center Hospital East ( Site 1504)

Kashiwa, Chiba, Japan

Site Status

Ehime University Hospital ( Site 1508)

Tōon, Ehime, Japan

Site Status

Sapporo Medical University Hospital ( Site 1501)

Sapporo, Hokkaido, Japan

Site Status

University of Tsukuba Hospital ( Site 1503)

Tsukuba, Ibaraki, Japan

Site Status

Yokosuka Kyosai Hospital ( Site 1509)

Yokosuka, Kanagawa, Japan

Site Status

Nara Medical University Hospital ( Site 1510)

Kashihara, Nara, Japan

Site Status

Saitama Medical University International Medical Center ( Site 1505)

Hidaka, Saitama, Japan

Site Status

Chiba Cancer Center ( Site 1506)

Chiba, , Japan

Site Status

Harasanshin Hospital ( Site 1515)

Fukuoka, , Japan

Site Status

Hiroshima City Hiroshima Citizens Hospital ( Site 1513)

Hiroshima, , Japan

Site Status

Nagano Municipal Hospital ( Site 1516)

Nagano, , Japan

Site Status

Osaka Metropolitan University Hospital ( Site 1512)

Osaka, , Japan

Site Status

Tokushima University Hospital ( Site 1514)

Tokushima, , Japan

Site Status

Tokyo Medical and Dental University Hospital ( Site 1517)

Tokyo, , Japan

Site Status

Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0254)

Monterrey, Nuevo León, Mexico

Site Status

Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300)

Aguascalientes, , Mexico

Site Status

Centro Estatal de Cancerologia de Chihuahua ( Site 0253)

Chihuahua City, , Mexico

Site Status

Instituto Nacional de Cancerologia ( Site 0256)

Tlalpan, , Mexico

Site Status

Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 1068)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1062)

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Europejskie Centrum Zdrowia Otwock ( Site 1057)

Otwock, Masovian Voivodeship, Poland

Site Status

Luxmed Onkologia sp. z o. o. ( Site 1051)

Warsaw, Masovian Voivodeship, Poland

Site Status

Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1060)

Bielsko-Biala, Silesian Voivodeship, Poland

Site Status

Clinic of Bashkortostan State Medical University ( Site 0869)

Ufa, Baskortostan, Respublika, Russia

Site Status

Ivanovo Regional Oncology Dispensary ( Site 0852)

Ivanovo, Ivanovo Oblast, Russia

Site Status

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0861)

Krasnoyarsk, Krasnoyarsk Krai, Russia

Site Status

Kursk Regional Clinical Oncology Dispensary ( Site 0854)

Kursk, Kursk Oblast, Russia

Site Status

FSBI ""United Hospital with Polyclinic"" of the Administrative Department of the President of the Ru

Moscow, Moscow, Russia

Site Status

Central Clinical Hospital with outpatient Clinic ( Site 0856)

Moscow, Moscow, Russia

Site Status

Bayandin Murmansk Regional Clinical Hospital ( Site 0859)

Murmansk, Murmansk Oblast, Russia

Site Status

Volga District Medical Center Federal Medical and Biological Agency ( Site 0857)

Nizhny Novgorod, Nizhny Novgorod Oblast, Russia

Site Status

Omsk Clinical Oncology Dispensary ( Site 0865)

Omsk, Omsk Oblast, Russia

Site Status

Leningrad Regional Oncology Center ( Site 0868)

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

Clinical Hospital Saint Luka ( Site 0867)

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

Saratov State Medical University n.a. V.I.Razumovskiy ( Site 0866)

Saratov, Saratov Oblast, Russia

Site Status

National Cancer Center ( Site 1354)

Goyang-si, Kyonggi-do, South Korea

Site Status

Seoul National University Bundang Hospital ( Site 1356)

Seongnam-si, Kyonggi-do, South Korea

Site Status

Korea University Anam Hospital ( Site 1351)

Seoul, , South Korea

Site Status

Seoul National University Hospital ( Site 1352)

Seoul, , South Korea

Site Status

Asan Medical Center ( Site 1355)

Seoul, , South Korea

Site Status

Samsung Medical Center ( Site 1353)

Seoul, , South Korea

Site Status

Hospital San Pedro de Alcantara ( Site 0654)

Cáceres, Extremadura, Spain

Site Status

H. de Gerona Dr. Josep Trueta ( Site 0651)

Girona, Gerona, Spain

Site Status

Hospital Universitario Ramon y Cajal ( Site 0660)

Madrid, Madrid, Comunidad de, Spain

Site Status

Hospital Universitario Quiron Madrid ( Site 0657)

Pozuelo de Alarcón, Madrid, Comunidad de, Spain

Site Status

Instituto Valenciano de Oncologia - IVO ( Site 0662)

Valencia, Valenciana, Comunitat, Spain

Site Status

Hospital del Mar ( Site 0653)

Barcelona, , Spain

Site Status

Hospital Universitario San Carlos ( Site 0663)

Madrid, , Spain

Site Status

Hospital Universitario La Paz ( Site 0661)

Madrid, , Spain

Site Status

Hospital Nuestra Sra. de Valme ( Site 0658)

Seville, , Spain

Site Status

Laenssjukhuset Ryhov ( Site 1205)

Jönköping, Jönköping County, Sweden

Site Status

Akademiska Sjukhuset ( Site 1201)

Uppsala, Uppsala County, Sweden

Site Status

Cancercentrum ( Site 1204)

Umeå, Västerbotten County, Sweden

Site Status

Ramathibodi Hospital. ( Site 1451)

Bangkok, Bangkok, Thailand

Site Status

Faculty of Medicine Siriraj Hospital ( Site 1452)

Bangkok, Bangkok, Thailand

Site Status

Maharaj Nakorn Chiangmai Hospital ( Site 1453)

Chiang Mai, , Thailand

Site Status

Srinagarind Hospital ( Site 1454)

Khon Kaen, , Thailand

Site Status

Hacettepe Universitesi Tıp Fakultesi ( Site 0911)

Ankara, , Turkey (Türkiye)

Site Status

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0910)

Istanbul, , Turkey (Türkiye)

Site Status

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0906)

Istanbul, , Turkey (Türkiye)

Site Status

Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0901)

Istanbul, , Turkey (Türkiye)

Site Status

Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0909)

Konya, , Turkey (Türkiye)

Site Status

Sakarya Universitesi Tip Fakultesi ( Site 0913)

Sakarya, , Turkey (Türkiye)

Site Status

Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0904)

Trabzon, , Turkey (Türkiye)

Site Status

Cherkasy Regional Oncology Dispensary ( Site 0959)

Cherkasy, Cherkasy Oblast, Ukraine

Site Status

Regional Oncological Hospital ( Site 0956)

Dnipro, Dnipropetrovsk Oblast, Ukraine

Site Status

Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 0951)

Dnipro, Dnipropetrovsk Oblast, Ukraine

Site Status

MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 0963)

Dnipropetrovsk, Dnipropetrovsk Oblast, Ukraine

Site Status

Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 0969)

Kharkiv, Kharkivs’ka Oblast’, Ukraine

Site Status

CNPE "Regional Center of Oncology" ( Site 0958)

Kharkiv, Kharkivs’ka Oblast’, Ukraine

Site Status

National Cancer Institute of the MoH of Ukraine ( Site 0962)

Kyiv, Kyivska Oblast, Ukraine

Site Status

Lviv Regional Clinical Hospital ( Site 0955)

Lviv, Lviv Oblast, Ukraine

Site Status

Lviv State Oncology Regional Treatment and Diagnostic Center ( Site 0967)

Lviv, Lviv Oblast, Ukraine

Site Status

Kyiv City Clinical Oncology Center ( Site 0960)

Kyiv, , Ukraine

Site Status

Aberdeen Royal Infirmary ( Site 0708)

Aberdeen, Aberdeen City, United Kingdom

Site Status

Torbay Hospital ( Site 0704)

Torquay, Devon, United Kingdom

Site Status

Kent and Canterbury Hospital ( Site 0709)

Canterbury, England, United Kingdom

Site Status

Lister Hospital ( Site 0715)

Stevenage, Hertfordshire, United Kingdom

Site Status

The Royal Marsden Foundation Trust ( Site 0702)

London, London, City of, United Kingdom

Site Status

Imperial College Healthcare NHS Trust ( Site 0721)

London, London, City of, United Kingdom

Site Status

Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 0725)

Norwich, Norfolk, United Kingdom

Site Status

Royal Cornwall Hospital ( Site 0703)

Truro, , United Kingdom

Site Status

Countries

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United States Australia Belgium Canada Denmark France Germany Hungary Ireland Israel Italy Japan Mexico Poland Russia South Korea Spain Sweden Thailand Turkey (Türkiye) Ukraine United Kingdom

References

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Galsky MD, Hoimes CJ, Necchi A, Shore N, Witjes JA, Steinberg G, Bedke J, Nishiyama H, Fang X, Kataria R, Sbar E, Jia X, Siefker-Radtke A. Perioperative pembrolizumab therapy in muscle-invasive bladder cancer: Phase III KEYNOTE-866 and KEYNOTE-905/EV-303. Future Oncol. 2021 Aug;17(24):3137-3150. doi: 10.2217/fon-2021-0273. Epub 2021 May 19.

Reference Type DERIVED
PMID: 34008425 (View on PubMed)

Related Links

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Other Identifiers

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MK-3475-866

Identifier Type: OTHER

Identifier Source: secondary_id

KEYNOTE-866

Identifier Type: OTHER

Identifier Source: secondary_id

2080224790

Identifier Type: REGISTRY

Identifier Source: secondary_id

2022-501970-20-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

194870

Identifier Type: REGISTRY

Identifier Source: secondary_id

U1111-1282-6279

Identifier Type: REGISTRY

Identifier Source: secondary_id

2018-003808-39

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

3475-866

Identifier Type: -

Identifier Source: org_study_id

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