A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral GB2064 in Participants With Myelofibrosis

NCT ID: NCT04679870

Last Updated: 2024-04-03

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 21 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-06-09
• Study Completion Date: 2026-06-30

Brief Summary

This study is an open label, phase IIa trial in subjects with Myelofibrosis

Detailed Description

This study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered GB2064 a LOXL-2 inhibitor over 9 months. Subjects will receive doses of GB2064, given twice per day to participants with primary or secondary Myelofibrosis

Conditions

Myelofibrosis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

GB2064

GB2064 will be administered orally as 4 x 250 mg tablets twice a day.

Group Type: EXPERIMENTAL

GB2064

Intervention Type: DRUG

GB2064 (formerly PAT-1251) is a high-affinity, selective, mechanism-based, small molecule inhibitor of LOXL2, administered twice a day

Interventions

GB2064

GB2064 (formerly PAT-1251) is a high-affinity, selective, mechanism-based, small molecule inhibitor of LOXL2, administered twice a day

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

Participants must satisfy all of the following criteria at the Screening visit:

1. Adult male or female participants ≥ 18 years of age at enrolment:

1. Female participants may be of non-childbearing potential defined as permanently sterile or postmenopausal, or female participants considered to be of childbearing potential who agree to use highly effective birth control methods until 90 days after the follow-up visit. Female participants should refrain from ova donation from the date of Enrolment (Day -1) until 90 days after the follow-up visit.

2. Male participants will agree to use contraception throughout the study and until 90-days after the Follow-up visit. Male participants must agree to refrain from sperm donation from the date of Enrolment (Day -1) until 90 days after the follow-up visit.

2. Diagnosis of PMF or SMF with intermediate -2 or high-risk disease according to the Dynamic International Prognostic Scoring System (DIPSS)-plus or if with low risk disease then with symptomatic splenomegaly as defined by sonographic assessment as spleen length of >12 cm or by physical examination as ≥ 5 cm below left costal margin.

3. Participants who are not currently taking a Janus kinase (JAK) inhibitor (e.g. ruxolitinib or fedratinib) and are therefore refractory, intolerant or ineligible for a JAK inhibitor according to appropriate guidelines (including local guidelines).

4. Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

5. Required baseline laboratory status:

1. Absolute platelet count (APC) ≥ 50 x 109/L

2. Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (1500/mm3)

3. Serum direct bilirubin ≤ 2.0 x ULN (upper limit of normal)

4. AST (SGOT) or ALT (SGPT) [if both measured, then this applies to both measurements] ≤ 2.5 x ULN, except for participants with MF involvement of the liver who must have levels ≤ 5 x ULN

5. Estimated Glomerular Filtration Rate (eGFR) or creatinine clearance (CrCl) (CrCl calculated by the Cockroft and Gault method) ≥ 30 ml/min/1.73 m2.

6. Peripheral blood blasts <10%

6. Treatment-related toxicities from prior therapies must have resolved to Common Terminology Criteria for Adverse Events (CTCAE) Grade ≤ 1.

7. Participants must have a documented history of transfusion records (if there have been any such transfusions) in the preceding 12 weeks to Day 1.

Exclusion Criteria

1. Current treatment with a JAK inhibitor (e.g. ruxolitinib or fedratinib) or a history of treatment with a JAK inhibitor within two weeks of enrolment.

2. Positive hepatitis panel and/or positive HIV test.

3. Any concurrent severe and/or uncontrolled medical conditions that could increase the participant's risk for toxicity while in the study or that could confound discrimination between disease- and study treatment-related toxicities. Any planned major surgery during the study period

4. Impaired cardiac function or clinically significant cardiac diseases, including any of the following:

1. History or presence of ventricular tachyarrhythmia.

3. Clinically significant resting bradycardia (< 50 bpm) and use of a cardiac pacemaker or implantable cardioverter defibrillator.

4. Angina pectoris or acute myocardial infarction ≤ 90 days prior to starting study drug.

5. Other clinically significant heart disease (e.g., symptomatic congestive heart failure; uncontrolled arrhythmia or hypertension; history of labile hypertension or poor compliance with an antihypertensive regimen).

5. Participants who are currently receiving chronic (> 14 days) treatment with corticosteroids at a dose > 10 mg of prednisone (or its glucocorticoid equivalent) per day, or any other chronic immunosuppressive treatment that cannot be discontinued prior to starting study drug.

6. Participants with impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of GB2064 as per physician's opinion.

7. Participants who received radiotherapy within the last month prior to screening procedures, or patients who received splenectomy in the previous three months or are scheduled for the procedure in the next three months.

8. Participants who had a history of malignancy in the past 3 years, except for treated early stage squamous, basal cell carcinoma or treated, localised prostate cancer.

9. Presence of clinically meaningful active bacterial, fungal, parasitic or viral infection which requires therapy.

10. Previous history of Progressive Multifocal Leuko-encephalopathy (PML).

11. Pregnant or breast feeding (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive β- HCG laboratory test.

12. Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception during dosing and for 90 days after study treatment. Highly effective contraception methods must be used.

13. Sexually active males must use a condom during intercourse while taking the drug and for 90 days after stopping study drug and should not father a child in this period. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid.

14. Hypersensitivity to GB2064 and/or its excipients.

15. Participants unable or unwilling to comply with protocol requirements.

16. Participants related to PI/site staff.

17. Participants who have had a hematopoietic stem cell transplantation.

18. Participants who are eligible, have a donor and are willing to undergo a hematopoietic stem cell transplantation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

OPIS s.r.l

UNKNOWN

Sponsor Role: collaborator

Galecto Biotech AB

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Richard F Schlenk, MD

Role: PRINCIPAL_INVESTIGATOR

Universitätsklinikum Heidelberg, Germany

Locations

MD Andersson Cancer Hospital

Houston, Texas, United States

Woden Dermatology

Canberra, , Australia

Heinrich-Heine-University Dusseldorf

Düsseldorf, , Germany

Universitätsklinikum Heidelberg

Heidelberg, , Germany

Universität Leipzig

Leipzig, , Germany

Klinikum rechts der Isar der Technischen Universitaet Munchen

München, , Germany

University of Bologna Sant Orsola Malpighi

Bologna, , Italy

Azienda Ospedaliero-Universitaria Careggi

Florence, , Italy

ASST Grande Ospedale Metropolitano Niguarda

Milan, , Italy

Azienda Ospedaliero-Universitaria San Luigi Gonzaga di Orbassano

Orbassano, , Italy

Azienda Socio-Sanitaria Territoriale dei Sette Laghi

Varese, , Italy

Countries

United States; Australia; Germany; Italy

Other Identifiers

2020-003087-45

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

MYLOX-1

Identifier Type: -

Identifier Source: org_study_id