Police COVID-19 Serosurvey

NCT ID: NCT04643444

Last Updated: 2025-11-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1024 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-02-09
• Study Completion Date: 2022-06-30

Brief Summary

The investigators aim to determine the immune status of the employees of the cantonal police of Bern against SARS-CoV-2 over a period of 1 year, and to investigate the risk profile of the study participants and their risk of SARS-CoV-2 exposure in their working and private environments, as well as to evaluate the use of personal protective equipment at potential exposure instances.

Detailed Description

i) To determine the extent of infection with seroprevalence data in the special population of police officers of the canton Bern.

ii) To determine risk factors for infection by comparing the proportion of seropositivity (infected versus noninfected individuals). The investigators hypothesize that police officers with fieldwork activity will have a higher seroprevalence than will office and administration personnel. The investigators hypothesize that working in the city of Bern will be associated with a higher seroprevalence than will working in other geographic areas of the canton (i.e. rural area).

iii) To monitor COVID-19 antibody titres and neutralizing capacity over time and to associate them with reinfection rates and infection-free intervals in police officers after accidental contact with a proven COVID-19 case. The investigators hypothesize that in seropositive individuals, there will be a decreasing dynamic of antibody titres over the one-year study period, and hence, a decrease of neutralizing capacity.

Conditions

SARS-CoV-2 Infection; Volunteers; Healthy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Blood sampling

Testing for the presence of SARS-CoV-2 antibodies

Intervention Type: DIAGNOSTIC_TEST

Online Questionnaire

Questions on working place, risk profiles and PPE

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Police officers of the cantonal police of Bern volunteering to participate in the study.

Exclusion Criteria

• Refusal or inability to give informed consent or contraindication to venepuncture.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Interregionale Blutspende SRK Bern

UNKNOWN

Sponsor Role: collaborator

University of Bern

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Parham Sendi, MD

Role: PRINCIPAL_INVESTIGATOR

University of Bern

Locations

University of Bern, Institute for Infectious Diseases

Bern, Canton of Bern, Switzerland

Countries

Switzerland

References

Sendi P, Baldan R, Thierstein M, Widmer N, Gowland P, Gahl B, Buchi AE, Guntensperger D, Wider M, Blum MR, Tinguely C, Maillat C, Theel ES, Berbari E, Dijkman R, Niederhauser C. A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study. Open Forum Infect Dis. 2021 Oct 16;8(12):ofab524. doi: 10.1093/ofid/ofab524. eCollection 2021 Dec.

Reference Type: DERIVED

PMID: 34888394 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

2020-02650

Identifier Type: -

Identifier Source: org_study_id