Endoscopic Ruler for the Assessment of Variceal Bleeding Risks (CHESS2005)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

266 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-23

Study Completion Date

2025-01-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The presence of varices is a serious complication of portal hypertension in liver disease. To prevent variceal haemorrhage, screening and surveillance aims to detect high-risk varices related to varices size and determine the need for primary prophylaxis. Varices size evaluated by endoscopists might not be perfect reference, influenced by experience and machine. Endoscopic ruler is a novel tool to measure the varices size under the endoscopy. The investigators aim to evaluate the bias of varices size between endoscopists and endoscopic ruler as the reference.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

CHESS Criteria for Varices Screening in Compensated Advanced Chronic Liver Disease (CHESS2001/APPHA2001)

NCT04307264

Compensated Advanced Chronic Liver Disease Varices Needing Treatment

COMPLETED

Timing of Endoscopy for Acute Variceal Bleeding in Patients With Cirrhosis

NCT04957875

Cirrhosis, Liver Portal Hypertension Varice Bleed

COMPLETED

The Timing of Emergency Endoscopy for Esophagogastric Variceal Bleeding in Cirrhosis

NCT04932200

Liver Cirrhosis Portal Hypertension Esophageal Varix Bleeding

UNKNOWN

Noninvasive Tests to Predict the Presence of Esophageal Varices in Patients With Liver Cirrhosis

NCT03513887

Cirrhosis

COMPLETED

HVPG-guided Laparoscopic Versus Endoscopic Therapy for Variceal Rebleeding in Portal Hypertension: A Multicenter Randomized Controlled Trial (CHESS1803)

NCT03783065

Portal Hypertension Variceal Rebleeding

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Liver Cirrhosis Portal Hypertension Gastroesophageal Varices

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Overall eligible participants

Eligible participants whose varix size will be measured by endoscopists and endoscopic ruler will receive standard esophagogastroduodenoscopy

Endoscopic ruler

Intervention Type DIAGNOSTIC_TEST

Endoscopic ruler for varices in portal hypertension

Product uses: measuring the diameter of the veins under the endoscopy for the assessment of the risk of variceal haemorrhage in patients with portal hypertension

Black and white measuring rule is highly recognizable under the endoscopy

The width of each cell is 1 mm, and the measuring range is 0-10 mm

With smooth edge, safe and reliable

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Endoscopic ruler

Endoscopic ruler for varices in portal hypertension

Product uses: measuring the diameter of the veins under the endoscopy for the assessment of the risk of variceal haemorrhage in patients with portal hypertension

Black and white measuring rule is highly recognizable under the endoscopy

The width of each cell is 1 mm, and the measuring range is 0-10 mm

With smooth edge, safe and reliable

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age between 18 and 75 years
* clinically evident or biopsy-confirmed cirrhosis
* Varices diagnosed by endoscopy
* written informed consent

Exclusion Criteria

* red sign
* Active upper gastrointestinal bleeding

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Xiaolong Qi

Director, Institute of Portal Hypertension

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Xiaolong Qi, M.D.

Role: STUDY_CHAIR

LanZhou University

Fengmei Wang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Tianjin Second People's Hospital

Guoxin Zhang, M.D.

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital with Nanjing Medical University

Shengjuan Hu, M.D.

Role: PRINCIPAL_INVESTIGATOR

People's Hospital of Ningxia Hui Autonomous Region

Xianmei Meng, M.D.

Role: PRINCIPAL_INVESTIGATOR

The Second Affiliated Hospital of Baotou Medical College

Xiaoyan Wang, M.D.

Role: PRINCIPAL_INVESTIGATOR

The Third Xiangya Hospital of Central South University

Zhijie Feng, M.D.

Role: PRINCIPAL_INVESTIGATOR

The Second Hospital of Hebei Medical University

Muhan Lv, M.D.

Role: PRINCIPAL_INVESTIGATOR

The Affiliated Hospital Of Southwest Medical University

Yiling Li, M.D.

Role: PRINCIPAL_INVESTIGATOR

First Hospital of China Medical University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.