Efficacy and Safety of S (+) - Ibuprofen in Osteoarthritis Pain

NCT ID: NCT04637529

Last Updated: 2023-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

176 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-05

Study Completion Date

2023-06-30

Brief Summary

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The purpose of this study is to evaluate the efficacy of S (+) - ibuprofen compared to an active treatment for pain control in individuals diagnosed with osteoarthritis.

Detailed Description

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Conditions

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Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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S (+) - Ibuprofen

S (+) - Ibuprofen (1 coated tablet) + placebo of Ibuvix® - ibuprofen (1 coated tablet) Every 6 hours for 28 days.

Group Type EXPERIMENTAL

S (+) - Ibuprofen

Intervention Type DRUG

S (+) - Ibuprofen + placebo of Ibuvix®

Ibuvix® - ibuprofen

Ibuvix® - ibuprofen (1 coated tablet) + placebo of S (+) - Ibuprofen (1 coated tablet) Every 6 hours for 28 days.

Group Type ACTIVE_COMPARATOR

Ibuvix® - ibuprofen

Intervention Type DRUG

Ibuvix® + placebo of S(+) - Ibuprofen

Interventions

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S (+) - Ibuprofen

S (+) - Ibuprofen + placebo of Ibuvix®

Intervention Type DRUG

Ibuvix® - ibuprofen

Ibuvix® + placebo of S(+) - Ibuprofen

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Ability to confirm voluntary participation and agree to all trial purposes by signing and dating the informed consent forms;
* Patients aged from 18 to 75 with a diagnosis of knee and/or hip osteoarthritis according to American College of Rheumatology (ACR) criteria.

Exclusion Criteria

* Known hypersensitivity to the formula components used during the clinical trial;
* Previous history of alcohol or drugs abuse diagnosed by DSM-V;
* Current or previous history (less than 12 months) of smoking;
* Have clinically relevant abnormal laboratory results according to medical evaluation;
* Women who are pregnant, lactating, or positive for β - hCG urine test;
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Apsen Farmaceutica S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Apsen Farmacêutica S.A.

São Paulo, , Brazil

Site Status

Countries

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Brazil

Other Identifiers

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APS003/2020

Identifier Type: -

Identifier Source: org_study_id

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