Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
NCT ID: NCT03691818
Last Updated: 2020-01-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE2
353 participants
INTERVENTIONAL
2018-07-16
2019-10-21
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
NCT05324163
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis Knee Pain
NCT03081806
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis
NCT02067611
X-Ray Study Investigating The Safety And Efficacy Of SD-6010 In Subjects With Osteoarthritis Of The Knee
NCT01438918
Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee
NCT00689273
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Low-dose test drug group
X0002 Spray 1 Spray/time/Knee, 2 times/day; Ibuprofen Placebo Tab 400 mg/time, 3 times /day.
X0002 Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
Low-dose active drug control group
Ibuprofen Tablet 400 mg/time, 3 times /day; X0002 Placebo Spray 1 Spray/time/Knee, 2 times/day.
Ibuprofen Tablet
Ibuprofen Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Low-dose placebo control group
Placebo Spray 1 Spray/time/Knee, 2 times/day; Ibuprofen Placebo Tab 400 mg/time, 3 times/day.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Medium-dose test drug group
X0002 Spray 2 Spray/time/Knee, 2 times/day; Ibuprofen Placebo Tab 400 mg/time, 3 times /day.
X0002 Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
Medium-dose active drug control group
X0002 Placebo Spray 2 Spray/time/Knee, 2 times/day; Ibuprofen Tablet 400 mg/time, 3 times /day.
Ibuprofen Tablet
Ibuprofen Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Medium-dose placebo control group
X0002 Placebo Spray 2 Spray/time/Knee, 2 times/day; Ibuprofen Placebo Tab 400 mg/time, 3 times /day.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
High-dose test drug group
X0002 Spray 4 Spray/time/Knee, 2 times/day; Ibuprofen Placebo Tab 400 mg/time, 3 times /day.
X0002 Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
High-dose active drug control group
X0002 Placebo Spray 4 Spray/time/Knee, 2 times/day; Ibuprofen Tablet 400 mg/time, 3 times /day.
Ibuprofen Tablet
Ibuprofen Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
High-dose placebo control group
X0002 Placebo Spray 4 Spray/time/Knee, 2 times/day; Placebo Tablet 400 mg/time, 3 times /day.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
X0002 Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Ibuprofen Tablet
Ibuprofen Tab 400mg, tid.
Ibuprofen Placebo Tab
Ibuprofen Placebo Tab 400mg, tid.
X0002 Placebo Spray
According to the different dose groups assigned, each knee joint was sprayed with 1, 2 or 4 sprays.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2\. An understanding, ability, and willingness to fully comply with study procedures and restrictions.
3\. Subject must be a male or female between 40 and 75 years of age, inclusive.
4\. Female subjects must either not be of childbearing potential (defined as postmenopausal for at least 1 year or surgically sterile \[bilateral tubal ligation, bilateral oophorectomy, or hysterectomy\]) or be willing to practice at least 1 of the following medically acceptable methods of birth control: Hormonal methods such as oral, implantable, injectable, vaginal ring, or transdermal contraceptives for a minimum of 1 full cycle (based on the subjects usual menstrual cycle period) before study drug administration.
1. Intrauterine device.
2. Double-barrier method (condoms, sponge, or diaphragm with spermicidal jellies or cream).
5\. Subject must have a diagnosis of idiopathic OA according to the American College of Rheumatology clinical and radiographic criteria, and fulfillment of at least four of the 6 criteria: age of ≥50 years stiffness lasting \<30 minutes after getting up in the morning crepitus Bone tenderness Bone enlargement No joint fever
6\. Subject must have a history of clinically symptomatic OA of the knee for ≥6 months.
7\. Subject must have had knee pain while standing, walking, and/or in motion for at least 14 days during the month prior to screening.
8\. Subject must have a knee pain score ≥40 mm and \<90 mm on a 100 mm VAS (without analgesic medication) on at least 7 of the 10 days prior to randomization(according to the subject's diary card records).
9\. Subject must have a WOMAC pain average score of knee ≥40 mm and \<90 mm starting on the first screening visit.
10\. Subject must be willing to discontinue any NSAIDs or other analgesic (e.g. aspirin) or potentially confounding concomitant treatments (e.g. physiotherapy, acupuncture) starting on the first screening visit until completing participation in the study. (The use of ≤325 mg acetylsalicylic acid per day as cardiac prophylaxis is permitted.) The subject will be allowed to take rescue medication (acetaminophen) for pain during the study except during the 24 hours prior to the Second Screening Visit, Baseline (Day1), Week 2, Week 4, Week 8, Week 12, Week 14.
11\. Subject must be willing to discontinue applying any topical preparations containing Vitamin A acids \[including all trans-retinoic-acid (tretinoin), 13-cis-retinoic-acid (isotretinoin), 9-cis-retinoic-acid (alitretinoin), vitamin A (retinol), retinal, and their derivatives\] to the lower limbs starting on the first screening visit until completing participation in the study. (Topical preparations containing Vitamin A acids or retinol may be applied to areas of the skin above the waist, but should not be applied to areas of the skin exposed to study medication.) 12. Subject must be willing to avoid unaccustomed physical activity (e.g. starting a new weight lifting routine) for the duration of the study starting on the first screening visit.
13\. With the exception of OA of the knee, the subject must be in good general health with no clinically significant findings from medical history, vital signs, physical examination, ECG, and routine laboratory tests that could interfere with subject safety, or pain and functional assessments, as determined by the Investigator.
Exclusion Criteria
2\. Subject who has secondary OA of the knee or OA of lower limb joints other than the knee that in the opinion of the Investigator, could interfere with pain and functional assessments related to the knee.
3\. Subject who has a history of total or partial knee replacement, arthroplasty, or other knee surgery on either knee.
4\. Subject who has had significant injury, as estimated by the Investigator, involving the target knee within the 6 months before screening.
5\. Subject who has skin lesions or wounds on or near the knees to be treated at Screening or on Day 1 prior to the first administration of study medication.
6\. Subject who has used opiates or corticosteroids within 30 days before screening for the target knee or who requires treatment with chronic opiates or corticosteroids.
7\. Subject who has had intra articular injections of corticosteroids, hyaluronic acid, or viscosupplements (e.g. Synvisc®) to a knee to be treated within the 3 months before screening.
8\. Subject who has a history of significant hypersensitivity, intolerance, or allergy to ibuprofen, any NSAIDs, aspirin, or acetaminophen.
9\. Subject who has had an active peptic ulceration in the 6 months prior to screening or a history of gastrointestinal (GI) bleeding within 5 years of screening.
10\. Subject who has used an anticoagulant (except aspirin up to 325 mg/day for cardiac prophylaxis) in the month prior to Screening.
11\. Subject who has positive results on fecal occult blood testing at screening or on Day 1 prior to the first administration of study medication.
12\. Subject who has a history of chronic inflammatory disease (such as rheumatoid arthritis, psoriatic arthritis, gouty arthritis), fibromyalgia, or other conditions that may affect the target joint or the functional and pain assessments (e.g. osteonecrosis, chondrocalcinosis).
13\. Subject is an asthmatic requiring treatment with systemic corticosteroids. Asthmatic subjects using inhaled corticosteroids are eligible.
14\. Subject has any clinically significant unstable cardiac, respiratory, neurological, immunological, hematological, or renal disease, or any other condition that, in the investigators opinion, could compromise the subjects welfare, ability to communicate with the study staff, or otherwise contraindicate study participation.
15\. Subject has a significant renal or hepatic disease, as indicated by clinical laboratory assessment,defined as
1. aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase≥3 × the upper limit of normal
2. creatinine ≥1.5 × ULN
3. hemoglobin\<10g/dL.
16\. Subject has any other clinically significant laboratory finding at Screening that in the investigators opinion contraindicates study participation.
17\. Subject is receiving systemic chemotherapy, has an active malignancy of any type, or has been diagnosed with cancer within 5 years before Screening (excluding squamous or basal cell carcinoma of the skin).
18\. Subject has clinically significant abnormality on 12-lead ECG, including a QTc interval \>450 msecs for males and 470 msecs for females.
19\. Subject has uncontrolled hypertension defined as systolic blood pressure \>170 mmHg and diastolic blood pressure \>90 mmHg at baseline (may be repeated after 5 minutes rest to verify).
20\. Subject is female and pregnant, planning to become pregnant during the study, or nursing.
21\. Subject participated in a previous clinical study with bromine hydrochloride spray.
22\. Subjects with known alcohol or other substance abuse.
23\. Subject participated in any other clinical trial within the past 3 months or 5 half-lives, whichever is longer.
24\. Subject is a participating Investigator, sub-investigator, study coordinator, or employee of a participating Investigator, or is an immediate family member of the aforementioned.
25\. Any factor, which in the opinion of the Investigator would jeopardize the evaluation or safety or be associated with poor adherence to the protocol.
26\. Subjects without access to telephone and/or ability to gain technology access.
40 Years
75 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Tianjin XinChen-Techfields Pharma Co., LTD.
INDUSTRY
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Zeng Xiaofeng
Role: PRINCIPAL_INVESTIGATOR
lead institution
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Chinese Academy of Medical Science & Peking Union Medical college Hospital
Beijing, Beijing Municipality, China
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
TFR-X0002-201
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.