Effect of Muscle Relaxation Reversal on the Success Rate of Motor Evoked Potential Recording
NCT ID: NCT04608682
Last Updated: 2022-09-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
170 participants
INTERVENTIONAL
2021-08-16
2022-08-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Sugammadex group
Sugammadex
The muscle relaxant infusion will be discontinued and a bolus of sugammadex (2mg/kg) will be given while performing TceMEPs.
control group
Saline
The muscle relaxant infusion will be discontinued and 2ml saline will be infused, TceMEPs monitoring will be performed 5 minutes later.
Interventions
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Sugammadex
The muscle relaxant infusion will be discontinued and a bolus of sugammadex (2mg/kg) will be given while performing TceMEPs.
Saline
The muscle relaxant infusion will be discontinued and 2ml saline will be infused, TceMEPs monitoring will be performed 5 minutes later.
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) physical status I to II
Exclusion Criteria
* History of epilepsy or use of antiepileptic drugs
* Personal history or family history of malignant hyperthermia
* Allergies to sugammadex; NMBs or other medication(s) used during general anesthesia
* Hemoglobin \<110 g/L
* TceMEP stimulation or recorded site infection
* Preoperative neurological dysfunction in both upper extremities
* Cardiac pacemaker
* Pregnancy and lactation
18 Years
65 Years
ALL
No
Sponsors
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Beijing Tiantan Hospital
OTHER
Responsible Party
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Ruquan Han
Professor
Locations
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Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Countries
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References
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Jian M, Liu H, Liang F, Ma B, Wang L, Zhou Y, Qiao H, Han R, Wang C. Effect of intraoperative muscle relaxation reversal on the success rate of motor evoked potential recording in patients undergoing spinal surgery: a randomized controlled trial. BMC Anesthesiol. 2023 Aug 25;23(1):290. doi: 10.1186/s12871-023-02211-z.
Jian M, Ma B, Liu H, Wang C, Liang F, Zhou Y, Qiao H, Han R. Effect of intraoperative muscle relaxation reversal on the success rate of motor-evoked potential recording in patients undergoing spinal surgery: study protocol for a randomised controlled trial. BMJ Open. 2022 May 2;12(5):e056571. doi: 10.1136/bmjopen-2021-056571.
Other Identifiers
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WJP20201030
Identifier Type: -
Identifier Source: org_study_id
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