Relationship of Endoplasmic Reticulum Stress and Adenoid Diseases
NCT ID: NCT04583631
Last Updated: 2021-09-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
54 participants
OBSERVATIONAL
2018-11-01
2019-08-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Chronic adenoiditis
Patients with hypertrophy and those out of hypertrophy were determined and those who had purulant rhinorrhea signs and rate of adenoids-choana below 50% were categorized that chronic adenoiditis.
Adenoidectomy surgery
All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers.
Adenoid hypertrophy
Patients who have snoring and those whose adenoid choana rate is greater than 50% were categorized that adenoid hypertrophy group.
Adenoidectomy surgery
All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers.
Interventions
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Adenoidectomy surgery
All patients underwent adenoidectomy under general anesthesia by routine curettage method and adenoid tissues were put in formaldehyde and sent to the genetics department for the exploration of ER stress and apoptosis markers.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Other otolaryngological
3 Years
9 Years
ALL
No
Sponsors
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Selcuk University
OTHER
Responsible Party
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Merih Onal
Assistant Professor
Locations
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Selcuk University
Konya, Selcuklu, Turkey (Türkiye)
Countries
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References
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Casselbrant ML. What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. Int J Pediatr Otorhinolaryngol. 1999 Oct 5;49 Suppl 1:S133-5. doi: 10.1016/s0165-5876(99)00147-0.
Li R, Wang Y, Chen P, Meng J, Zhang H. Inhibiting endoplasmic reticulum stress by activation of G-protein-coupled estrogen receptor to protect retinal astrocytes under hyperoxia. J Biochem Mol Toxicol. 2021 Feb;35(2):e22641. doi: 10.1002/jbt.22641. Epub 2020 Sep 29.
Other Identifiers
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2018-18
Identifier Type: -
Identifier Source: org_study_id
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