Regional COVID Epidemiology in England (RECEDE)

NCT ID: NCT04579562

Last Updated: 2020-10-08

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 5000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-11-01
• Study Completion Date: 2021-10-31

Brief Summary

The COVID-19 pandemic has exposed the unwanted variation in outcomes as evidence by Public Health England's report on increased mortality in regions of the country. For example, UHDB, in East Midlands, has reported a high crude mortality as compared to other Trusts in the region.8 There may also have been variation in the incidence of complications of COVID-19 in the form of AKI, which may have influenced mortality. Variation in outcomes may be because of various factors - differing population demographics, underlying health conditions in the population, deprivation, physician preference and knowledge and ethnic diversity. Unwanted variation is care that is not consistent with a patient's preference or related to [their] underlying illness. It is important to understand the reason for unwanted variation in outcomes associated with COVID-19 to minimise patient harm and reduce morbidity and mortality.

Conditions

Acute Kidney Injury

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

COVID-19 positive AKI

No intervention

Intervention Type: OTHER

This is observational, non-interventional study

COVID-19 positive no AKI

No intervention

Intervention Type: OTHER

This is observational, non-interventional study

COVID negative AKI

No intervention

Intervention Type: OTHER

This is observational, non-interventional study

Interventions

No intervention

This is observational, non-interventional study

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

This study will have two work packages (WP). Work Package 1 (WP1): Regional epidemiology of COVID-19 in England All patients who are admitted to hospital with COVID-19 infection between 1st March 2020 and 30th June 2020 and who meet following criteria will be included

1. Diagnostic code for COVID-19 (U07.1) in any of the 20 diagnoses codes

2. Adult patients greater or equal to 18 years of age.

Work Package 2 (WP2): Epidemiology of COVID-19 associated AKI in England All patients who are admitted to hospital with acute kidney injury (AKI) between 1st March 2020 and 30th June 2020 and who meet following criteria will be included

1. Diagnostic code for AKI (N17) in any of the 20 diagnoses codes

2. Adult patients greater or equal to 18 years of age.

Exclusion Criteria

WP1:

The following patients will be excluded from the study

1. Patients not admitted to the hospital

2. Paediatric patients < 18 years of age

WP2:

The following patients will be excluded from the study

1. Patients not admitted to the hospital

2. Paediatric patients < 18 years of age

3. Patients on chronic maintenance haemodialysis or peritoneal dialysis

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 110 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospitals of Derby and Burton NHS Foundation Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Nitin V Kolhe, DM

Role: CONTACT

nitin.kolhe@nhs.net

01332788266

References

Kolhe NV, Fluck R, Taal M. Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data. BMJ Open. 2025 Mar 15;15(3):e095020. doi: 10.1136/bmjopen-2024-095020.

Reference Type: DERIVED

PMID: 40090681 (View on PubMed)

Kolhe NV, Fluck RJ, Taal MW. Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infect Dis. 2024 Mar 22;24(1):346. doi: 10.1186/s12879-024-09210-6.

Reference Type: DERIVED

PMID: 38519921 (View on PubMed)

Other Identifiers

UHDB/2020/075

Identifier Type: -

Identifier Source: org_study_id