Copy Number Variation in Prenatal Diagnosis

NCT ID: NCT04561440

Last Updated: 2020-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

16000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-01

Study Completion Date

2020-12-30

Brief Summary

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An observed study is aim to map the CNVs distribution in human genome of Chinese prenatal population.

Setting: Prenatal diagnosis center of Taizhou City, Zhejiang Province Patient: total cases of pregnant women needed prenatal genetic diagnosing Methods: karyotype was performed with combined of molecular and cytogenic protocol. Subgroup: molecular karyotyping performed by genomic Chip (CMA) or NGS, the latter including cnv-seq and NIPT.

Main outcome: comparison of CNVs distributions in subgroups. Second outcome: comparison of CNVs distributions in demographic dates.

Detailed Description

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Conditions

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Copy Number Variation Genome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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molecular karyotyping

molecular karyotyping

Intervention Type DIAGNOSTIC_TEST

performed by NGS or CMA chip

cytogenic karyotyping

molecular karyotyping

Intervention Type DIAGNOSTIC_TEST

performed by NGS or CMA chip

Interventions

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molecular karyotyping

performed by NGS or CMA chip

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* total population need invasival prenatal diagnosis

Exclusion Criteria

* multipara
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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YiYang Zhu

OTHER

Sponsor Role lead

Responsible Party

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YiYang Zhu

vice dean of prenatal dignosis

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Taizhou Hospital of Zhejiang province

Taizhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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YiYang Zhu, MD

Role: primary

+8613819630569

Other Identifiers

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19EZZDC7

Identifier Type: -

Identifier Source: org_study_id

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