Efficacy of Blue Light Treatment in Patients With Nonseasonal Major Depressive Disorder

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

162 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2022-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To compare the efficacy of blue light, bright light and dim light in the treatment of with nonseasonal major depression disorder(MDD) in adults.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Efficacy and Safety of Light Therapy in the Treatment of Non-seasonal Depressive Disorder in Chinese Population

NCT05499117

Major Depressive Disorder

UNKNOWN NA

A Clinical Study of Light Therapy on Depressive Episodes of Bipolar Disorder

NCT02009371

Depressive Episodes of Bipolar Disorder

COMPLETED NA

Near-infrared Radiation-transcranial Photobiomodulation for Major Depressive Disorder

NCT04619121

Major Depressive Disorder Oxidative Stress

COMPLETED NA

The Efficacy and Feasibility of Bright Light Therapy in Adolescents With Depressive Disorder

NCT06913309

Depressive Disorder, Major

NOT_YET_RECRUITING NA

Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder

NCT04447430

Major Depressive Disorder

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The current study aims to compare the efficacy of blue light, bright light and dim light in the treatment of with nonseasonal major depression disorder(MDD) in adults. 162 patients with nonseasonal MDD will be randomized into three groups (i.e. blue light, bright light or dim light). The treatment will be performed five times a week for the first two weeks. And for the next 2 weeks, the treatment for patients will be undertook three times a week. There will be 16 times in total. The investigators will assess nonseasonal MDD'symptom severity in the baseline, 1 week,2 week, 4 week,6 week and 8 week. Through the study, 17-item Hamilton Depression Rating Scale (HAMD17),14-item Hamilton Anxiety Rating Scale (HAMA14),Quick Inventory of Depressive Symptoms, Self-Rated version (QIDS-SR)，Pittsburgh sleep quality index (PSQI) , Clinical Global Impression scale(CGI), Quality of Life, Enjoyment and Satisfaction Questionnaire (Q-LES-Q),Morningness-Eveningness Questionnaire (MEQ),Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),subjective fatigue symptom scale and semantic differential scale will be obtained. The patients will also get individual's data of heart rate and blood pressure.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Depression

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

blue light group

The blue light will be applied five times a week for the first two weeks. For the next two weeks, this treatment will be applied three times a week.

Group Type ACTIVE_COMPARATOR

blue light

Intervention Type DEVICE

Patients receive exposure to 100lux blue light, which dominant wave-length is 468nm for 30 minutes in the morning.

bright light group

The bright light will be applied five times a week for the first two weeks. For the next two weeks, this treatment will be applied three times a week.

Group Type ACTIVE_COMPARATOR

bright light

Intervention Type DEVICE

Patients receive exposure to 1000lux bright light, which dominant wave-length is 490nm for 30 minutes in the morning.

dim light group

The dim light will be applied five times a week for the first two weeks. For the next two weeks, this treatment will be applied three times a week.

Group Type PLACEBO_COMPARATOR

dim light

Intervention Type DEVICE

Patients receive exposure to 100lux dim light, which dominant wave-length is 490nm for 30 minutes in the morning.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blue light

Patients receive exposure to 100lux blue light, which dominant wave-length is 468nm for 30 minutes in the morning.

Intervention Type DEVICE

bright light

Patients receive exposure to 1000lux bright light, which dominant wave-length is 490nm for 30 minutes in the morning.

Intervention Type DEVICE

dim light

Patients receive exposure to 100lux dim light, which dominant wave-length is 490nm for 30 minutes in the morning.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* meet criteria for major depressive episodes as determined by MINI
* HAMD17≥17
* received antidepressive medication at stable dosages for at least 14 days

Exclusion Criteria

* Any axis I psychiatric disorder comorbidity
* who have received formal psychological therapy, MECT or rTMS in 3 months
* any current significant medical condition especially eye diseases
* serious suicide risk
* pregnant or breastfeeding women
* depression with seasonal pattern
* treatment-resistant depression
* epilepsy in the past

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No